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Tryptophan-tRNA Ligase

Known as: Tryptophanyl T RNA Synthetase, Ligase, Trp-tRNA, Trp tRNA Ligase 
An enzyme that activates tryptophan with its specific transfer RNA. EC 6.1.1.2.
National Institutes of Health

Papers overview

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Review
2019
Review
2019
  • M. Jin
  • Experimental & Molecular Medicine
  • 2019
  • Corpus ID: 57572832
Tryptophanyl tRNA synthetase (WRS) is an essential enzyme as it catalyzes the ligation of tryptophan to its cognate tRNA during… Expand
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Highly Cited
2003
Highly Cited
2003
Early forms of the genetic code likely generated “statistical” proteins, with similar side chains occupying the same sequence… Expand
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Highly Cited
2002
Highly Cited
2002
Aminoacyl-tRNA synthetases catalyze the first step of protein synthesis. It was shown recently that human tyrosyl-tRNA synthetase… Expand
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Highly Cited
2002
Highly Cited
2002
The 20 aminoacyl-tRNA synthetases catalyze the first step of protein synthesis and establish the rules of the genetic code… Expand
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Highly Cited
1998
Highly Cited
1998
Alterations in the rate of cellular tryptophan metabolism are involved in mediating important biological activities associated… Expand
Highly Cited
1996
Highly Cited
1996
Sequence-specific interactions between aminoacyl-tRNA synthetases and their cognate tRNAs both ensure accurate RNA recognition… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Tryptophanyl-tRNA synthetase (TrpRS) catalyzes activation of tryptophan by ATP and transfer to tRNA(Trp), ensuring… Expand
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Highly Cited
1977
Highly Cited
1977
  • C. Yanofsky
  • Journal of molecular biology
  • 1977
  • Corpus ID: 36571968
A mutant altered in the sole structural gene for tRNATrp produces sevenfold elevated levels of trp operon enzymes and messenger… Expand
Highly Cited
1968
Highly Cited
1968
Fourteen mutant strains of Escherichia coli were examined, each of which requires tryptophan for growth but is unaltered in any… Expand
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