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Tropomyosin Alpha-1 Chain, human

Known as: Sarcomeric Tropomyosin Kappa, Tropomyosin-1, Tropomyosin Alpha-1 Chain 
Tropomyosin alpha-1 chain (284 aa, ~33 kDa) is encoded by the human TPM1 gene. This protein plays a role in muscle contraction.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Background: Exosomes can transfer information between cells and facilitate tumor development. Results: PC12 cell-derived exosomes… Expand
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Highly Cited
2007
Highly Cited
2007
Dilated cardiomyopathy and hypertrophic cardiomyopathy (HCM) can be caused by mutations in thin filament regulatory proteins of… Expand
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Highly Cited
2005
Highly Cited
2005
Dilated cardiomyopathy (DCM), characterized by cardiac dilatation and contractile dysfunction, is a major cause of heart failure… Expand
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Highly Cited
2001
Highly Cited
2001
Proteins in cardiac myocytes assemble into contractile units known as sarcomeres. Contractile force is generated by interaction… Expand
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Highly Cited
2000
Highly Cited
2000
Central core disease (CCD) and nemaline myopathy (NM) are congenital myopathies for which differential diagnosis is often based… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The molecular basis of idiopathic dilated cardiomyopathy, a primary myocardial disorder that results in reduced… Expand
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Highly Cited
1997
Highly Cited
1997
A method has been developed for culturing cardiac myocytes in a collagen matrix to produce a coherently contracting 3-dimensional… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Familial hypertrophic cardiomyopathy can be caused by mutations in the genes for beta cardiac myosin heavy chain… Expand
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Highly Cited
1994
Highly Cited
1994
We demonstrate that missense mutations (Asp175Asn; Glu180Gly) in the alpha-tropomyosin gene cause familial hypertrophic… Expand
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Highly Cited
1984
Highly Cited
1984
Five polyheptapeptides (Ac-(Lys-Leu-Glu-Ala-Leu-Glu-Gly)n-Lys-amide, where n = 1-5) of 8, 15, 22, 29, and 36 residues were… Expand
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