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Trimethadione

Known as: Trimethinum, Trimethadionum, 2,4-Oxazolidinedione, 3,5,5-trimethyl- 
A dione-type anticonvulsant with antiepileptic activity. Trimethadione reduces T-type calcium currents in thalamic neurons, thereby stabilizing… 
National Institutes of Health

Related topics

Related topics

21 relations

Broader (2)

AnticonvulsantsOxazoles
Antiepileptic AgentsChildhood Absence EpilepsyDrug AllergyEpilepsy

Narrower (2)

TridioneTrimetin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Time course of the demethylation of trimethadione.
A gas chromatographic method for the determination of trimethadione in the serum is described. By this method, the time course of… 
1998
1998
Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice.
Highly Cited
1987
Highly Cited
1987
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Highly Cited
1980
Highly Cited
1980
Pharmacological modification of amygdaloid-kindled seizures
Highly Cited
1979
Highly Cited
1979
Effects of some anti-epileptic, neuroleptic and gabaminergic drugs on convulsions induced by D,L-allyglycine
1974
1974
The interaction of lupus-inducing drugs with deoxyribonucleic acid.
1973
1973
Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro.
Review
1968
Review
1968
Epilepsy in Jerusalem, Israel
Epileptic disorders of unknown cause in Jerusalem, Israel, which were diagnosed during the period January, 1958, through December… 
Review
1965
Review
1965
A study of the product of demethylation of trimethadione in the control of petit mal epilepsy
SEVERAL N-methylated derivatives of barbituric acid, hydantoin, and 2,4-oxazolidinedione have had extensive use in the treatment… 
1960
1960
THE ANTICONVULSANT PROPERTIES OF 2‐METHYL‐3‐p‐BROMOPHENYL‐3H‐4‐QUINAZOLONE HYDROCHLORIDE (B.D.H. 1880) AND SOME RELATED COMPOUNDS
Twenty‐five 2‐alkyl‐3‐aryl‐3H‐4‐quinazolone derivatives, eight 2‐aryl‐3‐alkyl‐3H‐4‐quinazolone derivatives and six 2‐alkyl‐3‐aryl… 
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