Trimethadione

Known as: Trimethinum, Trimethadionum, 2,4-Oxazolidinedione, 3,5,5-trimethyl- 
A dione-type anticonvulsant with antiepileptic activity. Trimethadione reduces T-type calcium currents in thalamic neurons, thereby stabilizing… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2015
05101519462014

Papers overview

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Highly Cited
2005
Highly Cited
2005
Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that… (More)
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2005
2005
The purpose of the present study was to explore the analgesic effects of the low voltage-activated T-type Ca2+ channel blockers… (More)
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Highly Cited
2001
Highly Cited
2001
Originally described as a model of 'psychomotor seizures' (J. Pharmacol. Exp. Ther. (1953) 107-273), the 6 Hz corneal stimulation… (More)
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1999
1999
This report describes studies of anticonvulsants for the organophosphorus (OP) nerve agent soman: a basic research effort to… (More)
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1996
1996
Spontaneous generalized epileptiform discharges were elicited in rodent thalamocortical slices by perfusion with a medium… (More)
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1986
1986
Lamotrigine (LTG), 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, is a structurally novel anticonvulsant. The anticonvulsant… (More)
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1983
1983
Three experiments were performed in order to develop a murine model of the postnatal functional defects recently described in… (More)
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1977
1977
We describe a family in which seven pregnancies resulted in four infants who died and in three abortions. During these… (More)
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1975
1975
Three families are described in which each of the mothers took trimethadione during pregnancy. From a comparison of siblings in… (More)
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1964
1964
Several central depressant and other drugs have been examined for their effects upon acetylcholine release from the stimulated… (More)
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