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Trifluridine

Known as: Trifluoromethyldeoxyuridine, 5 Trifluoromethyl 2' deoxyuridine, Thymidine, alpha,alpha,alpha-trifluoro- 
A fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase… 
National Institutes of Health

Related topics

Related topics

24 relations

Broader (2)

AntimetabolitesAntiviral Agents
Drug AllergyIn BloodKeratitis, HerpeticKeratoconjunctivitis, Infectious

Narrower (6)

LonsurfTAS 102ViromidinViroptic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1989
1989
Effect of oleic acid on diffusion of drugs through hairless mouse skin.
The effect of oleic acid in propylene glycol or 2-ethyl-1,3-hexanediol vehicle systems on the skin permeability of 17 beta… 
1987
1987
Differential effects of radical scavengers on X-ray-induced mutation and cytotoxicity in human cells.
The cytotoxic and mutagenic effects of X irradiation on a human lymphoblast cell line were examined in the presence of two… 
1986
1986
Evaluation of the effect of agar on the results obtained in the L5178Y mouse lymphoma assay.
The L5178Y TK+/- mouse lymphoma assay is widely used in mutagenicity testing. Trifluorothymidine-resistant (TFTr) mutants are… 
1984
1984
Effect of azone and propylene glycol on penetration of trifluorothymidine through skin and efficacy of different topical formulations against cutaneous herpes simplex virus infections in guinea pigs
Tropical formulations of 5-trifluoromethyl-2'-deoxyuridine (TFT) containing different concentrations of TFT, Azone (Nelson… 
1983
1983
Inhibition of human cytomegalovirus by trifluorothymidine
The antiviral activity of trifluorothymidine (TFT) singly and in combination with other antiviral agents against human… 
1982
1982
Induction of neuroblastoma maturation by a new chemotherapy protocol.
Five patients, 1.5 to 9 years old, were treated at M.D. Anderson Hospital for Stage III of IV neuroblastoma. Each was entered… 
1979
1979
[Herpes simplex virus isolations from the aqueous humor of patients suffering from focal iritis, endotheliitis, and prolonged disciform keratitis with glaucoma (author's transl)].
Aqueous humor from 33 herpes patients, 4 zoster patients, and 14 patients with etiologically unclear anterior uveitis was… 
1977
1977
Corneal wound healing and antiviral medication.
Masked, controlled rabbit studies were done to determine the toxic effects on corneal wound healing of 0.1 percent idoxuridine… 
1976
1976
Growth inhibition of cells in cultures and of vaccinia virus infected HeLa cells by derivatives of trifluorothymidine.
The effects of 5-trifluoromethyluracil (F3Thy), 5-trifluoromethyl-2'-deoxyuridine (F3dThd), F3dThd-5'-P, and F3dThd-5… 
1972
1972
Target-Organ Treatment of Neurotropic Virus Diseases: Efficacy as a Chemotherapy Tool and Comparison of Activity of Adenine Arabinoside, Cytosine Arabinoside, Idoxuridine, and Trifluorothymidine
A sensitive in vivo system was studied for use in evaluating relatively small quantities of antiviral compounds. Swiss mice were… 
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