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Tribbles Homolog 2

Known as: TRB-2, TRIB2 
Tribbles homolog 2 (343 aa, ~39 kDa) is encoded by the human TRIB2 gene. This protein is involved in the modulation of MAP kinase activation.
National Institutes of Health

Related topics

Related topics

6 relations
CytoskeletonEnzyme Activity AlterationLeukocytesSignal Transduction

Papers overview

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2020
2020
LncRNA XIST promotes the progression of laryngeal squamous cell carcinoma via sponging miR-125b-5p to modulate TRIB2
OBJECTIVE X inactivate-specific transcript (XIST) is an attractive long noncoding RNA (lncRNA) functioning as an indicator of… 
2018
2018
TRIB2 regulates the differentiation of MLL–TET1 transduced myeloid progenitor cells
The function and mechanism of action of MLL–TET1 (MT1) fusion protein in hematological cells are unclear and require further… 
2018
2018
TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells.
Acquired resistance to chemotherapy plays a critical role in human drug treatment failure in many tumor types. Multidrug… 
2018
2018
A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling
Trib2 pseudokinase is involved in the etiology of a number of cancers including leukaemia, melanoma, ovarian, lung and liver… 
2017
2017
An adaptive variant of TRIB2, rs1057001, is associated with higher expression levels of thermogenic genes in human subcutaneous and visceral adipose tissues
An obesity-related single-nucleotide polymorphism (SNP) of the Tribbles pseudokinase 2 gene (TRIB2) was shown to have underwent… 
2016
2016
Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice
Tribbles homolog 2 (Trib2) is a member of Tribbles protein pseudokinases and involves in apoptosis, autoimmunity, cancer… 
2016
2016
TRIB2 Regulates the Cell Cycle Under Stress Conditions in a Murine Cell Model of Leukaemia
Background: TRIB2 is a known oncogene in different leukemias (AML, T-ALL) and can interact with different signalling pathways… 
Review
2015
Review
2015
Tribbles in normal and malignant haematopoiesis
The tribbles protein family, an evolutionarily conserved group of pseudokinases, have been shown to regulate multiple cellular… 
2014
2014
Investigating the role and function of Tribbles 2 (TRIB2) in drug resistance within cancer
2011
2011
The Growth Factor Independence 1 variant form GFI136N Predisposes to Acute Myeloid Leukemia by Inducing Epigenetic Changes in Oncogenes Such As Hoxa9
Abstract 223 A coding variant form of GFI1 (GFI136N) increases the risk to develop AML by 60% and is present in about 10–15… 
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