Transthyretin Antisense Oligonucleotide ISIS-TTR Rx

Known as: ISIS-TTR Rx, ISIS-TTRRx, TTR ASO ISIS-TTR Rx 
An antisense oligonucleotide (ASO) targeting transthyretin (TTR), which has potential use in the treatment of TTR amyloidosis (ATTR). Upon… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2016
024619982016

Papers overview

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Highly Cited
2016
Highly Cited
2016
OBJECTIVE To examine safety, tolerability, pharmacokinetics, and preliminary clinical efficacy of intrathecal nusinersen… (More)
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2016
2016
Transthyretin amyloidosis (ATTR amyloidosis) is a rare disease that results from the deposition of misfolded transthyretin (TTR… (More)
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2016
2016
Familial amyloid polyneuropathy (FAP) is caused by mutations of the transthyretin (TTR) gene, predominantly expressed in the… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Lipoprotein(a) (Lp[a]) is a risk factor for cardiovascular disease and calcific aortic valve stenosis. No effective… (More)
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2015
2015
INTRODUCTION This randomized, double-blind, phase II study evaluated the pharmacodynamics, safety and tolerability of ISIS 329993… (More)
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2015
2015
C-reactive protein (CRP) is known to be strongly associated with atrial fibrillation (AF). However, it is not clear if CRP is a… (More)
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2014
2014
BACKGROUND C-reactive protein (CRP) binds to damaged cells, activates the classical complement pathway, is elevated in multiple… (More)
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Highly Cited
2012
Highly Cited
2012
Transthyretin (TTR)-associated amyloidosis is a late-onset autosomal-dominant genetic disease. Over 100 amyloidogenic mutations… (More)
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2011
2011
Four new polyoxygenated steroids (1-4) together with four known ones (5-8) have been isolated from the gorgonian Isis hippuris… (More)
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2005
2005
Eleven new hippuristanols (1-4, 7-9, and 11-14), along with eight known metabolites (5, 6, 10, and 15-19), have been isolated… (More)
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