Transcription Coactivator

Known as: Transcriptional Activator/Coactivator, Transcriptional Activator, Transcription Factor Coactivator 
A transcription cofactor that activates transcription from a RNA polymerase II promoter but does not bind DNA itself.
National Institutes of Health

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CCCTC-binding factor, humanCEBPE protein, humanCITED2 protein, humanCREBBP protein, human
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Papers overview

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Review
2017
Review
2017
Plant genome editing with TALEN and CRISPR
Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on… (More)
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Review
2017
Review
2017
Delivery technologies for genome editing
With the recent development of CRISPR technology, it is becoming increasingly easy to engineer the genome. Genome-editing systems… (More)
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Highly Cited
2008
Highly Cited
2008
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.
Ischaemia of the heart, brain and limbs is a leading cause of morbidity and mortality worldwide. Hypoxia stimulates the secretion… (More)
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Highly Cited
2005
Highly Cited
2005
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.
In lower organisms, increased expression of the NAD-dependent deacetylase Sir2 augments lifespan. The mechanism through which… (More)
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Highly Cited
2002
Highly Cited
2002
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.
Endurance exercise induces increases in mitochondria and the GLUT4 isoform of the glucose transporter in muscle. Although little… (More)
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Highly Cited
2001
Highly Cited
2001
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the… (More)
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Highly Cited
2001
Highly Cited
2001
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity.
Expanded polyglutamine repeats have been proposed to cause neuronal degeneration in Huntington's disease (HD) and related… (More)
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Highly Cited
1998
Highly Cited
1998
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a… (More)
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Highly Cited
1998
Highly Cited
1998
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300.
The transcriptional activity of NF-kappa B is stimulated upon phosphorylation of its p65 subunit on serine 276 by protein kinase… (More)
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Highly Cited
1993
Highly Cited
1993
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
We have designed a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety… (More)
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