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Transcription Coactivator
Known as:
Transcriptional Activator/Coactivator
, Transcriptional Activator
, Transcription Factor Coactivator
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A transcription cofactor that activates transcription from a RNA polymerase II promoter but does not bind DNA itself.
National Institutes of Health
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Related topics
Related topics
50 relations
CCCTC-binding factor, human
CEBPE protein, human
CITED2 protein, human
CREBBP protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Z. Arany
,
S. Foo
,
+10 authors
B. Spiegelman
Nature
2008
Corpus ID: 2993933
Ischaemia of the heart, brain and limbs is a leading cause of morbidity and mortality worldwide. Hypoxia stimulates the secretion…
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Highly Cited
2005
Highly Cited
2005
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α*
S. Nemoto
,
M. Fergusson
,
T. Finkel
Journal of Biological Chemistry
2005
Corpus ID: 11722973
In lower organisms, increased expression of the NAD-dependent deacetylase Sir2 augments lifespan. The mechanism through which…
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Review
2003
Review
2003
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
P. Puigserver
,
B. Spiegelman
Endocrine reviews
2003
Corpus ID: 35074591
Investigations of biological programs that are controlled by gene transcription have mainly studied the regulation of…
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Highly Cited
2002
Highly Cited
2002
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1
K. Baar
,
A. Wende
,
+5 authors
J. Holloszy
FASEB journal : official publication of the…
2002
Corpus ID: 7930279
Endurance exercise induces increases in mitochondria and the GLUT4 isoform of the glucose transporter in muscle. Although little…
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Highly Cited
2001
Highly Cited
2001
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
J. C. Yoon
,
P. Puigserver
,
+9 authors
B. Spiegelman
Nature
2001
Corpus ID: 11184579
Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the…
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Highly Cited
1998
Highly Cited
1998
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
P. Puigserver
,
Zhidan Wu
,
C. Park
,
R. Graves
,
M. Wright
,
B. Spiegelman
Cell
1998
Corpus ID: 17430488
Highly Cited
1997
Highly Cited
1997
Exploring the metabolic and genetic control of gene expression on a genomic scale.
J. Derisi
,
V. Iyer
,
P. Brown
Science
1997
Corpus ID: 302230
DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation…
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Highly Cited
1995
Highly Cited
1995
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Miyashita Toshiyuki
,
John Calvin Reed
Cell
1995
Corpus ID: 14495370
Highly Cited
1993
Highly Cited
1993
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
A. Brand
,
N. Perrimon
Development
1993
Corpus ID: 8536961
We have designed a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety…
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Highly Cited
1989
Highly Cited
1989
A novel genetic system to detect proteinprotein interactions
S. Fields
,
O. Song
Nature
1989
Corpus ID: 4320733
PROTEIN-protein interactions between two proteins have generally been studied using biochemical techniques such as crosslinking…
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