Skip to search formSkip to main contentSkip to account menu

Transcription Coactivator

Known as: Transcriptional Activator/Coactivator, Transcriptional Activator, Transcription Factor Coactivator 
A transcription cofactor that activates transcription from a RNA polymerase II promoter but does not bind DNA itself.
National Institutes of Health

Related topics

Related topics

50 relations
CCCTC-binding factor, humanCEBPE protein, humanCITED2 protein, humanCREBBP protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Ischaemia of the heart, brain and limbs is a leading cause of morbidity and mortality worldwide. Hypoxia stimulates the secretion… 
Highly Cited
2005
Highly Cited
2005
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α*
In lower organisms, increased expression of the NAD-dependent deacetylase Sir2 augments lifespan. The mechanism through which… 
Review
2003
Review
2003
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
Investigations of biological programs that are controlled by gene transcription have mainly studied the regulation of… 
Highly Cited
2002
Highly Cited
2002
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1
Endurance exercise induces increases in mitochondria and the GLUT4 isoform of the glucose transporter in muscle. Although little… 
Highly Cited
2001
Highly Cited
2001
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the… 
Highly Cited
1998
Highly Cited
1998
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Highly Cited
1997
Highly Cited
1997
Exploring the metabolic and genetic control of gene expression on a genomic scale.
DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation… 
Highly Cited
1995
Highly Cited
1995
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Highly Cited
1993
Highly Cited
1993
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
We have designed a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety… 
Highly Cited
1989
Highly Cited
1989
A novel genetic system to detect protein–protein interactions
PROTEIN-protein interactions between two proteins have generally been studied using biochemical techniques such as crosslinking… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License