Tosyllysine Chloromethyl Ketone

Known as: TLCK, Chlorotosylamidoaminoheptanone, Benzenesulfonamide, N-(5-amino-1-(chloroacetyl)pentyl)-4-methyl- 
An inhibitor of SERINE ENDOPEPTIDASES. Acts as an alkylating agent and is known to interfere with the translation process.
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
In this report, we have characterized two metacaspases of Leishmania donovani, L. donovani metacaspase-1 (LdMC1) and LdMC2. These… (More)
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Highly Cited
2000
Highly Cited
2000
Recombinant adenovirus (rAd) infection is one of the most effective and frequently employed methods to transduce dendritic cells… (More)
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Highly Cited
1999
Highly Cited
1999
Vascular endothelial growth factor (VEGF) has been suggested to play a role in the pathogenesis of diabetic vascular… (More)
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1997
1997
Specific interactions between parasites and extracellular matrix components are an important mechanism in the dissemination of… (More)
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1996
1996
pp70(s6k) is a mitogen-regulated serine/threonine kinase involved in the G1 to S phase transition of the cell cycle. We have… (More)
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Highly Cited
1996
Highly Cited
1996
Curcumin, widely used as a spice and coloring agent in food, possesses potent antioxidant, anti-inflammatory and anti-tumor… (More)
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Highly Cited
1995
Highly Cited
1995
Human leukemia U937 cells are induced to undergo apoptosis by several chemotherapeutic agents; however, the cellular components… (More)
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Highly Cited
1995
Highly Cited
1995
Apoptosis was induced in THP.1 cells, a human monocytic tumour cell line, by diverse stimuli including cycloheximide… (More)
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Highly Cited
1989
Highly Cited
1989
The role of cysteine proteinases in adherence of Trichomonas vaginalis NYH 286 to HeLa and human vaginal epithelial cells was… (More)
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Highly Cited
1988
Highly Cited
1988
Genistein inhibited topoisomerase II and I; it increased the enzyme-DNA complex in L1210 cells at 1 micrograms/ml, and interfered… (More)
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