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Tolazamide

Known as: N-(P-Toluenesulfonyl)-n'-hexamethyleniminourea, Tolazamidum, 1-(hexahydro-1-Azepinyl)-3-P-tolylsulfonylurea 
An intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. Tolazamide is converted into five major metabolites that are… Expand
National Institutes of Health

Related topics

Related topics

15 relations
Diabetes Mellitus, Non-Insulin-DependentIn BloodPregnancySulfonylurea Compounds
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Broader (1)

Hypoglycemic Agents

Narrower (1)

Tolinase

Papers overview

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Highly Cited
2002
Highly Cited
2002
Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass…
An atmospheric pressure chemical ionization liquid chromatographic-mass spectrometric (APCI-LC-MS) LC-MS assay is presented for… Expand
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Highly Cited
1996
Highly Cited
1996
Individual Sulfonylureas and Serious Hypoglycemia in Older People
OBJECTIVE: To compare the risk of serious hypoglycemia associated with the use of individual sulfonylureas in older people. 
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Highly Cited
1992
Highly Cited
1992
Brand Loyalty, Entry, and Price Competition in Pharmaceuticals after the 1984 Drug Act
IN 1984, Congress enacted a new law that greatly affected the economics of the pharmaceutical industry in the United States. It… Expand
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Highly Cited
1988
Highly Cited
1988
Characterization of the sulfonylurea receptor on beta cell membranes.
Specific, high affinity sulfonylurea receptors were characterized on membranes of an insulin-secreting hamster beta cell line… Expand
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Highly Cited
1986
Highly Cited
1986
Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus.
To determine whether sulfonylureas and exogenous insulin have different effects on insulin action, we studied eight patients with… Expand
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1984
1984
Lichenoid drug reactions to chlorpropamide and tolazamide.
: Many medications, including gold, antimalarials, quinidine, and thiazide diuretics have been implicated in lichenoid drug… Expand
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Highly Cited
1981
Highly Cited
1981
In vitro effects of a sulfonylurea on insulin action in adipocytes. Potentiation of insulin-stimulated hexose transport.
The mechanism(s) by which the oral sulfonylurea, tolazamide, exerts its extrapancreatic hypoglycemic effects was studied using… Expand
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1980
1980
Impaired Granulocyte Adherence in Mildly Diabetic Patients: Effects of Tolazamide Treatment
Granulocyte adherence in 10 of 15 untreated asymptomatic hyperglycemic diabetic outpatients (mean fasting glucose ± SEM, 289 ± 16… Expand
  • table 1
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1980
1980
Pseudoinsulinoma syndrome from inadvertent tolazamide ingestion.
A 70-year-old woman with rheumatoid arthritis presented with fasting hypoglycemia, inappropriately elevated insulin and C-peptide… Expand
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1956
1956
Ineffectiveness of Sulfonylureas in Alloxan Diabetic Rats.∗
Summary Oral administration of 100 mg 1-3-butyl-p-tolylsulfonylurea per kg body weight to normal rats results in a marked… Expand
  • figure 1
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