............................................................................................................................................ 3 Abbreviatons ...................................................................................................................................... 4 Introduction ............................................................................................................................... 5-10 Aims................................................................................................................................................. 10 Materials .................................................................................................................................... 11-12 Methods ..................................................................................................................................... 13-17 Results........................................................................................................................................ 16-33 Discussion .................................................................................................................................. 34-37 Acknowledgments ............................................................................................................................ 37 References .................................................................................................................................. 38-43 Appendix .................................................................................................................................... 44-45