Thymine DNA Glycosylase

Known as: DNA Glycosylase, Thymine, Thymine Glycol Glycosylase, Thymine DNA Glycosylase [Chemical/Ingredient] 
An enzyme that removes THYMINE and URACIL bases mispaired with GUANINE through hydrolysis of their N-glycosidic bond. These mispaired nucleotides… (More)
National Institutes of Health

Papers overview

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2014
2014
The E3 ubiquitin ligase CRL4(Cdt2) targets proteins for destruction in S phase and after DNA damage by coupling ubiquitylation to… (More)
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Review
2013
Review
2013
DNA methylation has a profound impact on genome stability, transcription and development. Although enzymes that catalyse DNA… (More)
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Highly Cited
2012
Highly Cited
2012
Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a key oxidation product of 5-methylcytosine… (More)
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Highly Cited
2012
Highly Cited
2012
Methylation of cytosine in DNA (5mC) is an important epigenetic mark that is involved in the regulation of genome function… (More)
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Highly Cited
2011
Highly Cited
2011
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas methyltransferases mediate cytosine methylation, it… (More)
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Highly Cited
2011
Highly Cited
2011
Thymine DNA glycosylase (TDG) excises T from G·T mispairs and is thought to initiate base excision repair (BER) of deaminated 5… (More)
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Highly Cited
2005
Highly Cited
2005
Members of the small ubiquitin-like modifier (SUMO) family can be covalently attached to the lysine residue of a target protein… (More)
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Highly Cited
2003
Highly Cited
2003
Human thymine-DNA glycosylase (TDG) is well known to excise thymine and uracil from G.T and G.U mismatches, respectively, and was… (More)
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Highly Cited
2002
Highly Cited
2002
DNA repair in chromatin is subject to topological constraints, suggesting a requirement for chromatin modification and remodeling… (More)
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Highly Cited
1999
Highly Cited
1999
In vitro, following the removal of thymine from a G.T mismatch, thymine DNA glycosylase binds tightly to the apurinic site it has… (More)
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