Thymidylate synthase inhibitor

Known as: Thymidylate Synthetase Inhibitors 
Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the… (More)
National Institutes of Health

Papers overview

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2005
2005
BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into alpha-folate receptor… (More)
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2004
2004
RNA interference is a post-transcriptional mechanism by which double-stranded RNA specifically silence expression of a… (More)
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Review
1998
Review
1998
Following the demonstration of efficacy, tolerability and quality-of-life benefits of raltitrexed ('Tomudex'), principally in… (More)
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Highly Cited
1997
Highly Cited
1997
Oxaliplatin, classical [5-fluorouracil (5-FU)] and non-classical (AG337) thymidylate synthase inhibitors have shown promising… (More)
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Review
1995
Review
1995
ZD1694 (Tomudex) is a new antifolate which is a specific inhibitor of thymidylate synthase (TS). Evidence suggests that ZD1694… (More)
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Highly Cited
1995
Highly Cited
1995
PURPOSE To determine the toxicities, maximal-tolerated dose (MTD), pharmacokinetic profile, and potential antitumor activity of… (More)
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1995
1995
Four cell lines, the mouse L1210 leukaemia, the human W1L2 lymphoblastoid and two human ovarian (CH1 and 41M) cell lines, were… (More)
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1993
1993
We have investigated the mechanism of inactivation of thymidylate synthase (TS) by ICI D1694 (a folate-based quinazoline) in… (More)
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Highly Cited
1991
Highly Cited
1991
N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is a water… (More)
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Highly Cited
1991
Highly Cited
1991
The thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) inhibits the growth of human lung carcinoma A549… (More)
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