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Thymidylate synthase inhibitor

Known as: Thymidylate Synthetase Inhibitors 
Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the… 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography.
Thymidylate synthase (EC 2.1.1.45) is a key enzyme for the de novo synthesis of DNA and as such a target for anticancer drug… 
Highly Cited
2004
Highly Cited
2004
A randomized trial comparing defined-duration with continuous irinotecan until disease progression in fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer.
PURPOSE Irinotecan given until disease progression is an accepted standard treatment for advanced colorectal cancer (CRC… 
2003
2003
A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.
PURPOSE ZD9331 is a novel, direct-acting antifolate cytotoxic that does not require polyglutamation for activity, and is a… 
1999
1999
The plasma pharmacokinetics and cerebrospinal fluid penetration of the thymidylate synthase inhibitor raltitrexed (TomudexTM) in a nonhuman primate model
Purpose: Raltitrexed (Tomudex™), ZD1694) is a novel quinazoline folate analog that selectively inhibits thymidylate synthase… 
1998
1998
Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model.
The purpose of this study was to determine the intestinal absorption characteristics of AG337, a mechanism-based inhibitor of… 
1995
1995
Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3,4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridplthio)-quinazolone dihydrochloride…
3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)quinazobone dihydrochboride (AG337) is a nonclassical inhibitor of… 
Review
1994
Review
1994
The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.
Thymidylate synthase (TS) is regarded as a good target for the development of quinazoline (folate-based) anticancer agents. The… 
1989
1989
Synthesis and biological activity of analogues of diazaquinomycin A, a new thymidylate synthase inhibitor.
Diazaquinomycin A (1), a new thymidylate (TMP) synthase inhibitor, is poorly soluble in various solvents and exhibits no… 
1987
1987
Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB 3717).
CB 3717, N10-propargyl-5,8-dideazafolic acid, is a tight-binding inhibitor of thymidylate synthase (TS) whose cytotoxicity is… 
1985
1985
DNA amplification in antifolate-resistant Leishmania. The thymidylate synthase-dihydrofolate reductase gene and abundant mRNAs.
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