Tetrahydrobiopterin

Known as: 2-Amino-6-(1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydoro-4(1H)-Pteridinone, 5,6,7,8-Tetrahydro-2-Amino-6-(1,2-Dihydroxypropyl)-4(1H)-Pteridinone, L-Erythro-2-Amino-6-(1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydro-4(3H)- Pteridinon 
A cofactor that is essential for the activity of aromatic amino acid hydroxylases. Tetrahydrobiopterin degrades phenylalanine, and facilitates the… (More)
National Institutes of Health

Papers overview

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Review
2011
Review
2011
BH4 (6R-L-erythro-5,6,7,8-tetrahydrobiopterin) is an essential cofactor of a set of enzymes that are of central metabolic… (More)
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Highly Cited
2006
Highly Cited
2006
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of… (More)
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Review
2004
Review
2004
Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a key signaling molecule in vascular homeostasis… (More)
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Highly Cited
2003
Highly Cited
2003
Tetrahydrobiopterin is a critical cofactor for the NO synthases, and in its absence these enzymes become "uncoupled," producing… (More)
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Highly Cited
2003
Highly Cited
2003
Tetrahydrobiopterin (BH4) serves as a critical co-factor for the endothelial nitric-oxide synthase (eNOS). A deficiency of BH4… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Altered endothelial cell nitric oxide (NO(*)) production in atherosclerosis may be due to a reduction of intracellular… (More)
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Highly Cited
2000
Highly Cited
2000
Aims/hypothesis. Tetrahydrobiopterin is an essential cofactor of nitric oxide synthase, and its deficiency decreases nitric oxide… (More)
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Highly Cited
1999
Highly Cited
1999
Subsaturating levels of tetrahydrobiopterin (BH(4)), an essential cofactor for nitric oxide synthase (NOS), can lead to… (More)
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Highly Cited
1998
Highly Cited
1998
It has been previously shown that besides synthesizing nitric oxide (NO), neuronal and inducible NO synthase (NOS) generates… (More)
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Highly Cited
1998
Highly Cited
1998
Constitutive nitric oxide synthase (cNOS) with insufficient cofactor (6R)-5,6,7,8-tetrahydrobiopterin (H4B) may generate damaging… (More)
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