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Tetrahydrobiopterin

Known as: 2-Amino-6-(1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydoro-4(1H)-Pteridinone, 5,6,7,8-Tetrahydro-2-Amino-6-(1,2-Dihydroxypropyl)-4(1H)-Pteridinone, L-Erythro-2-Amino-6-(1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydro-4(3H)- Pteridinon 
A cofactor that is essential for the activity of aromatic amino acid hydroxylases. Tetrahydrobiopterin degrades phenylalanine, and facilitates the… Expand
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO· synthase (eNOS) is responsible for… Expand
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Highly Cited
2006
Highly Cited
2006
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of… Expand
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Review
2004
Review
2004
  • N. Alp, K. Channon
  • Arteriosclerosis, thrombosis, and vascular…
  • 2004
  • Corpus ID: 12097590
Abstract—Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a key signaling molecule in vascular… Expand
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Highly Cited
2003
Highly Cited
2003
Tetrahydrobiopterin is a critical cofactor for the NO synthases, and in its absence these enzymes become "uncoupled," producing… Expand
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Highly Cited
2003
Highly Cited
2003
Tetrahydrobiopterin (BH4) serves as a critical co-factor for the endothelial nitric-oxide synthase (eNOS). A deficiency of BH4… Expand
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Highly Cited
2001
Highly Cited
2001
Background — Altered endothelial cell nitric oxide (NO·) production in atherosclerosis may be due to a reduction of intracellular… Expand
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Highly Cited
2000
Highly Cited
2000
Conditions associated with impaired nitric oxide (NO) activity and accelerated atherosclerosis have been shown to be associated… Expand
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Highly Cited
1999
Highly Cited
1999
Subsaturating levels of tetrahydrobiopterin (BH(4)), an essential cofactor for nitric oxide synthase (NOS), can lead to… Expand
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Highly Cited
1999
Highly Cited
1999
Abstract Serum phenylalanine concentrations decreased in 4 patients with hyperphenylalaninemia after loading with… Expand
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Highly Cited
1989
Highly Cited
1989
A new metabolic pathway characterized recently that is expressed in activated macrophages involves the formation of nitric oxide… Expand
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