Tetrabenazine

Known as: Tetrabenzaine, Tetrabenazine Orphan Brand, 2-oxo-3-Isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bh-benzo[a]quinolizine 
A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic… (More)
National Institutes of Health

Papers overview

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2009
2009
Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in Huntingtin protein (Htt… (More)
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2002
2002
Tetrabenazine (TBZ), a monoamine depleter and dopamine receptor blocker, is used to treat a variety of hyperkinetic movement… (More)
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Highly Cited
2000
Highly Cited
2000
Microtubule polymerization is initiated from the microtubule organizing centre (MTOC), which contains the gamma-tubulin complex… (More)
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1999
1999
OBJECTIVE Tetrabenazine, a monoamine depleter and dopamine receptor blocker, is used to treat several hyperkinetic movement… (More)
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Highly Cited
1998
Highly Cited
1998
To investigate the role of microtubules in regulating cell polarity in Schizosaccharomyces pombe, we have developed a system in… (More)
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Highly Cited
1997
Highly Cited
1997
Over the past 15 years we have treated 526 patients with severe hyperkinetic movement disorders with tetrabenazine (TBZ), a… (More)
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Highly Cited
1992
Highly Cited
1992
A cDNA for a rat vesicular monoamine transporter, designated MAT, was isolated by expression cloning in a mammalian cell line (CV… (More)
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1988
1988
Dopamine receptor blocking drugs, commonly used in the treatment of involuntary movements, may cause potentially serious adverse… (More)
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1985
1985
Four patients suffered acute dystonic reactions caused by tetrabenazine. Because dystonic reactions have previously been reported… (More)
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1975
1975
Different groups of mice were injected s.c. daily with lithium chloride in three doses (0.52, 1.58 and 4.72meq/kg) or with saline… (More)
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