Temocapril

Known as: (2S-(2alpha,6beta(R*)))-6-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid, Temocaprilum 
 
National Institutes of Health

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temocapril hydrochloride

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Highly Cited
2006
Highly Cited
2006
Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.
OBJECTIVE Recent reports have shown that genetic polymorphisms in organic anion transporting polypeptide (OATP) 1B1 have an… (More)
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Highly Cited
2005
Highly Cited
2005
Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats.
Whether temporary angiotensin II (AngII) blockade at the prediabetic stage attenuates renal injury in type 2 diabetic OLETF rats… (More)
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Highly Cited
2004
Highly Cited
2004
Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity.
OBJECTIVE Based on results of in vitro studies, it has been hypothesized that blockade of the renin-angiotensin system (RAS… (More)
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Highly Cited
2004
Highly Cited
2004
Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress.
OBJECTIVE Asymmetric dimethylarginine (ADMA) is widely believed to be an endogenous nitric oxide synthase (eNOS) inhibitor… (More)
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Highly Cited
2003
Highly Cited
2003
Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension.
Adiponectin, an adipocyte-derived protein, has been suggested to play an important role in insulin sensitivity. We examined the… (More)
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Highly Cited
2002
Highly Cited
2002
ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO.
Improvement of insulin resistance by ACE inhibitors has been suggested; however, this mechanism has not been proved. We… (More)
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2002
2002
Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression
Thioredoxin (TRX) is a redox regulatory protein that protects cells from various stresses. Angiotensin-converting enzyme (ACE… (More)
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Highly Cited
2000
Highly Cited
2000
Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters.
BACKGROUND Because hepatocyte growth factor (HGF) prevented and/or regressed fibrosis in liver and pulmonary injury models, HGF… (More)
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2000
2000
Temocapril, an angiotensin converting enzyme inhibitor, protects against diabetes-induced endothelial dysfunction.
The effect of chronic treatment with the angiotensin converting enzyme inhibitor, temocapril, on prevention of endothelial… (More)
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Highly Cited
1997
Highly Cited
1997
Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis.
We have shown previously that angiotensin-converting enzyme (ACE) inhibitors prevent coronary vascular remodeling (medial… (More)
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