Telomelysin
National Institutes of Health
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TPS4145 Background: Although checkpoint inhibitors (CPIs) can produce durable responses in gastric cancer patients (pts) in the…
On paper at least, the telomerase enzyme seems like a perfect cancer target. Telomerase expression is essential for the…
This study investigated the pathway underlying the antitumor activity of telomelysin, a telomerase‐dependent, replication…
PurposeA telomerase-specific oncolytic adenovirus, Telomelysin, can selectively kill cancer cells, and be attenuated in normal…
Multimodal approaches combining drugs that differentially function is the most popular regimen for treating human cancer…
S cientists are targeting telom-erase in various ways to kill cancer cells. Most recently, a team led by in Dallas, used an…
We previously constructed telomerase-dependent, replication-selective adenoviruses OBP-301 (Telomelysin) and OBP-401 [Telomelysin…
Telomelysin (OBP-301) is a telomerase-specific replication-component adenovirus. Telomelysin has a human telomerase reverse…
SummaryWe constructed a replication-competent oncolytic adenovirus, OBP-301 (Telomelysin), in which human telomerase reverse…