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Talampanel

Known as: (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine, 1-(4'-aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5-h)benzodiazepine 
A synthetic derivative of dioxolo-benzodiazepine with anti-seizure activity. Talampanel antagonizes the AMPA (alpha-amino-3-hydroxy-5-methyl-4… Expand
National Institutes of Health

Papers overview

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2011
2011
Abstract We tested the efficacy of treatment with talampanel in a mutant SOD1 mouse model of ALS by measuring intracellular… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE Novel agents are currently combined with radiation and temozolomide (RT + TMZ) in newly diagnosed glioblastoma using… Expand
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Highly Cited
2010
Highly Cited
2010
Abstract Our objective was to determine if chronic treatment with the non-competitive AMPA antagonist talampanel is efficacious… Expand
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2010
2010
BACKGROUND : Glioma cells secrete glutamate and also express alpha-amino-3-hydroxy-5 methyl-4-isoxazolepropionate (AMPA… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE Recent data suggest that the glutamatergic system is important in the proliferation and migration of glioblastoma… Expand
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2009
2009
PURPOSE To test the efficacy of the novel candidate anticonvulsant talampanel (GYKI 53773) in a rodent model of hypoxic neonatal… Expand
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Review
2006
Review
2006
There is a remarkable array of new chemical entities in the current antiepileptic drug (AED) development pipeline. In some cases… Expand
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2003
2003
PURPOSE Talampanel (LY300164), a potent and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-receptor… Expand
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2002
2002
The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial… Expand
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2001
2001
Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active… Expand
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