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Talampanel

Known as: (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine, 1-(4'-aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5-h)benzodiazepine 
A synthetic derivative of dioxolo-benzodiazepine with anti-seizure activity. Talampanel antagonizes the AMPA (alpha-amino-3-hydroxy-5-methyl-4… 
National Institutes of Health

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4 relations

Narrower (3)

GYKI 53405GYKI 53773LY 300164
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)
Highly Cited
2010
Highly Cited
2010
A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis
Abstract Our objective was to determine if chronic treatment with the non-competitive AMPA antagonist talampanel is efficacious… 
Highly Cited
2010
Highly Cited
2010
Survival of Patients with Newly Diagnosed Glioblastoma Treated with Radiation and Temozolomide in Research Studies in the United States
Purpose: Novel agents are currently combined with radiation and temozolomide (RT + TMZ) in newly diagnosed glioblastoma using… 
Highly Cited
2009
Highly Cited
2009
Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial.
PURPOSE Recent data suggest that the glutamatergic system is important in the proliferation and migration of glioblastoma… 
Review
2009
Review
2009
Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.
Review
2007
Review
2007
Progress report on new antiepileptic drugs: A summary of the Eigth Eilat Conference (EILAT VIII)
Review
2006
Review
2006
Diverse mechanisms of antiepileptic drugs in the development pipeline
Review
2004
Review
2004
Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII)
Review
2002
Review
2002
Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI)
Highly Cited
2002
Highly Cited
2002
A crossover, add-on trial of talampanel in patients with refractory partial seizures
Abstract—The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory… 
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