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Talampanel

Known as: (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine, 1-(4'-aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5-h)benzodiazepine 
A synthetic derivative of dioxolo-benzodiazepine with anti-seizure activity. Talampanel antagonizes the AMPA (alpha-amino-3-hydroxy-5-methyl-4… Expand
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (3)

GYKI 53405GYKI 53773LY 300164
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically
Abstract We tested the efficacy of treatment with talampanel in a mutant SOD1 mouse model of ALS by measuring intracellular… Expand
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Highly Cited
2010
Highly Cited
2010
Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States.
PURPOSE Novel agents are currently combined with radiation and temozolomide (RT + TMZ) in newly diagnosed glioblastoma using… Expand
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Highly Cited
2010
Highly Cited
2010
A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis
Abstract Our objective was to determine if chronic treatment with the non-competitive AMPA antagonist talampanel is efficacious… Expand
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2010
2010
Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas.
BACKGROUND : Glioma cells secrete glutamate and also express alpha-amino-3-hydroxy-5 methyl-4-isoxazolepropionate (AMPA… Expand
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Highly Cited
2009
Highly Cited
2009
Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial.
PURPOSE Recent data suggest that the glutamatergic system is important in the proliferation and migration of glioblastoma… Expand
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2009
2009
Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model.
PURPOSE To test the efficacy of the novel candidate anticonvulsant talampanel (GYKI 53773) in a rodent model of hypoxic neonatal… Expand
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Review
2006
Review
2006
Diverse mechanisms of antiepileptic drugs in the development pipeline
There is a remarkable array of new chemical entities in the current antiepileptic drug (AED) development pipeline. In some cases… Expand
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2003
2003
Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy.
PURPOSE Talampanel (LY300164), a potent and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-receptor… Expand
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2002
2002
A crossover, add-on trial of talampanel in patients with refractory partial seizures.
The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial… Expand
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2001
2001
Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats.
Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active… Expand
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