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Talampanel

Known as: (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine, 1-(4'-aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5-h)benzodiazepine 
A synthetic derivative of dioxolo-benzodiazepine with anti-seizure activity. Talampanel antagonizes the AMPA (alpha-amino-3-hydroxy-5-methyl-4… Expand
National Institutes of Health

Papers overview

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2011
2011
Abstract We tested the efficacy of treatment with talampanel in a mutant SOD1 mouse model of ALS by measuring intracellular… Expand
Highly Cited
2010
Highly Cited
2010
Purpose: Novel agents are currently combined with radiation and temozolomide (RT + TMZ) in newly diagnosed glioblastoma using… Expand
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Highly Cited
2010
Highly Cited
2010
Abstract Our objective was to determine if chronic treatment with the non-competitive AMPA antagonist talampanel is efficacious… Expand
Highly Cited
2010
Highly Cited
2010
Glioma cells secrete glutamate and also express α‐amino‐3‐hydroxy‐5 methyl‐4‐isoxazolepropionate (AMPA) glutamate receptors… Expand
Highly Cited
2009
Highly Cited
2009
PURPOSE Recent data suggest that the glutamatergic system is important in the proliferation and migration of glioblastoma… Expand
2009
2009
Purpose:  To test the efficacy of the novel candidate anticonvulsant talampanel (GYKI 53773) in a rodent model of hypoxic… Expand
Review
2006
Review
2006
There is a remarkable array of new chemical entities in the current antiepileptic drug (AED) development pipeline. In some cases… Expand
Highly Cited
2003
Highly Cited
2003
Summary:  Purpose: Talampanel (LY300164), a potent and selective α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionate (AMPA)‐receptor… Expand
Highly Cited
2002
Highly Cited
2002
Abstract—The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory… Expand
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Highly Cited
2001
Highly Cited
2001
Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active… Expand