FAQ

Talampanel

Known as: (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine, 1-(4'-aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5-h)benzodiazepine 
A synthetic derivative of dioxolo-benzodiazepine with anti-seizure activity. Talampanel antagonizes the AMPA (alpha-amino-3-hydroxy-5-methyl-4… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
024620002017

Related topics

Related topics

3 relations

Narrower (3)

GYKI 53405GYKI 53773LY 300164

Related mentions per year

Related mentions per year

1995-2017
1990200020102020
Talampanel
LY 300164
GYKI 53773
GYKI 53405

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically
We tested the efficacy of treatment with talampanel in a mutant SOD1 mouse model of ALS by measuring intracellular calcium levels… (More)
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2010
2010
Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas.
BACKGROUND : Glioma cells secrete glutamate and also express alpha-amino-3-hydroxy-5 methyl-4-isoxazolepropionate (AMPA… (More)
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Highly Cited
2010
Highly Cited
2010
Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States.
PURPOSE Novel agents are currently combined with radiation and temozolomide (RT + TMZ) in newly diagnosed glioblastoma using… (More)
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2010
2010
A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis.
Our objective was to determine if chronic treatment with the non-competitive AMPA antagonist talampanel is efficacious and safe… (More)
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2009
2009
Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model.
PURPOSE To test the efficacy of the novel candidate anticonvulsant talampanel (GYKI 53773) in a rodent model of hypoxic neonatal… (More)
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2009
2009
Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial.
PURPOSE Recent data suggest that the glutamatergic system is important in the proliferation and migration of glioblastoma… (More)
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2003
2003
Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy.
PURPOSE Talampanel (LY300164), a potent and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-receptor… (More)
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2002
2002
A crossover, add-on trial of talampanel in patients with refractory partial seizures.
The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial… (More)
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2002
2002
Protective effect of the antiepileptic drug candidate talampanel against AMPA-induced striatal neurotoxicity in neonatal rats.
2,3-Benzodiazepines represent a family of specific, noncompetitive AMPA receptor antagonists with anticonvulsant and… (More)
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2001
2001
Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats.
Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active… (More)
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