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Tafamidis meglumine

Known as: D-Glucitol, 1-Deoxy-1-(Methylamino)-, 2-(3,5-Dichlorophenyl)-6-Benzoxazolecarboxylate (1:1), D-Gluco-2,3,4,5,6-Pentahydroxy-N-Methylhexan-1-Aminium 2-(3,5-Dichlorophenyl)Benzoxazole-6-Carboxylate 
A soft gelatin capsule formulation containing the meglumine salt form of tafamidis, a small molecule and pharmacological chaperone with potential… Expand
National Institutes of Health

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Fx-1006A
TAFAMIDIS MEGLUMINE 20 mg ORAL CAPSULE [Vyndaqel]tafamidis

Papers overview

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2018
2018
Tafamidis delays neurological progression comparably across Val30Met and non‐Val30Met genotypes in transthyretin familial amyloid polyneuropathy
To better characterize the effects of tafamidis in non‐Val30Met patients with transthyretin familial amyloid polyneuropathy, this… Expand
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Review
2017
Review
2017
The endoplasmic reticulum: A hub of protein quality control in health and disease
Abstract One third of the eukaryotic proteome is synthesized at the endoplasmic reticulum (ER), whose unique properties provide a… Expand
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Highly Cited
2016
Highly Cited
2016
Early intervention with tafamidis provides long-term (5.5-year) delay of neurologic progression in transthyretin hereditary amyloid polyneuropathy
Abstract Transthyretin hereditary amyloid polyneuropathy, also traditionally known as transthyretin familial amyloid… Expand
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Review
2016
Review
2016
Current and future treatment of amyloid diseases.
There are more than 30 human proteins whose aggregation appears to cause degenerative maladies referred to as amyloid diseases or… Expand
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Highly Cited
2013
Highly Cited
2013
Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy
Tafamidis, a transthyretin (TTR) kinetic stabilizer, delayed neuropathic progression in patients with Val30Met TTR familial… Expand
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Highly Cited
2013
Highly Cited
2013
Effects of Tafamidis on Transthyretin Stabilization and Clinical Outcomes in Patients with Non-Val30Met Transthyretin Amyloidosis
This phase II, open-label, single-treatment arm study evaluated the pharmacodynamics, efficacy, and safety of tafamidis in… Expand
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2013
2013
Tafamidis (Vyndaqel): A Light for FAP Patients
Slowing FAP progression: Tafamidis meglumine is a small molecule capable of stabilizing the transthyretin (TTR) tetramer… Expand
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Highly Cited
2012
Highly Cited
2012
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy… Expand
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2012
2012
Familial amyloidotic polyneuropathy: current and emerging treatment options for transthyretin-mediated amyloidosis
  • E. Hund
  • The application of clinical genetics
  • 2012
    • Corpus ID: 2496002
Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a fatal clinical disorder characterized by extracellular deposition of… Expand
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Review
2011
Review
2011
Familial amyloid polyneuropathy
Familial amyloid polyneuropathies (FAPs) are a group of life-threatening multisystem disorders transmitted as an autosomal… Expand
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