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Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishing array of complex and chemically challenging reactions across… Expand Amniotic membrane-based tissue-engineered corneal epithelium has been widely used in the reconstruction of the ocular surface… Expand Background: 4-Demethylwyosine synthase (TYW1) is a tRNA-modifying metalloenzyme involved in the biosynthesis of wyosine. Results… Expand TYW1 catalyzes the condensation of N-methylguanosine with two carbon atoms from an unknown second substrate to form 4… Expand Background: Yeast cells respond to high environmental iron by altering gene transcription. Results: The high iron-sensing… Expand Question: Is there a pattern in growth of annual rings in roots of perennial forbs in relation to climate and climate extremes in… Expand Wye bases are tricyclic bases that are found in archaeal and eukaryotic tRNAs. The most modified wye base, wybutosine, which… Expand Wyosine and its derivatives, such as wybutosine, found in eukaryotic and archaeal tRNAs, are tricyclic hypermodified nucleosides… Expand Abstract Human kallikrein 1-related peptidases (KLKs) form a subfamily of 15 extracellular (chymo)tryptic-like serine proteases… Expand Wybutosine (yW) is a tricyclic nucleoside with a large side chain found at the 3′‐position adjacent to the anticodon of… Expand