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TYW1 gene

Known as: TYW1A, MGC23001, tRNA-yW synthesizing protein 1 homolog A (S. cerevisiae) 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
On the Role of Additional [4Fe-4S] Clusters with a Free Coordination Site in Radical-SAM Enzymes
The canonical CysXXXCysXXCys motif is the hallmark of the Radical-SAM superfamily. This motif is responsible for the ligation of… 
Review
2016
Review
2016
Radical S-Adenosylmethionine Enzymes in Human Health and Disease.
Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishing array of complex and chemically challenging reactions across… 
2014
2014
Xenogeneic Acellular Conjunctiva Matrix as a Scaffold of Tissue-Engineered Corneal Epithelium
Amniotic membrane-based tissue-engineered corneal epithelium has been widely used in the reconstruction of the ocular surface… 
2012
2012
4-Demethylwyosine Synthase from Pyrococcus abyssi Is a Radical-S-adenosyl-l-methionine Enzyme with an Additional [4Fe-4S]+2 Cluster That Interacts with the Pyruvate Co-substrate*
Background: 4-Demethylwyosine synthase (TYW1) is a tRNA-modifying metalloenzyme involved in the biosynthesis of wyosine. Results… 
2011
2011
Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.
TYW1 catalyzes the condensation of N-methylguanosine with two carbon atoms from an unknown second substrate to form 4… 
2011
2011
Yap5 Protein-regulated Transcription of the TYW1 Gene Protects Yeast from High Iron Toxicity*
Background: Yeast cells respond to high environmental iron by altering gene transcription. Results: The high iron-sensing… 
2007
2007
Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis.
Wye bases are tricyclic bases that are found in archaeal and eukaryotic tRNAs. The most modified wye base, wybutosine, which… 
Highly Cited
2007
Highly Cited
2007
Defining the extended substrate specificity of kallikrein 1-related peptidases
Abstract Human kallikrein 1-related peptidases (KLKs) form a subfamily of 15 extracellular (chymo)tryptic-like serine proteases… 
Highly Cited
2007
Highly Cited
2007
Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA.
Highly Cited
2006
Highly Cited
2006
Biosynthesis of wybutosine, a hyper‐modified nucleoside in eukaryotic phenylalanine tRNA
Wybutosine (yW) is a tricyclic nucleoside with a large side chain found at the 3′‐position adjacent to the anticodon of… 
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