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TXNRD1 wt Allele

Known as: TR, Trxr1, GRIM12 
Human TXNRD1 wild-type allele is located within 12q23-q24.1 and is approximately 135 kb in length. This allele, which encodes thioredoxin reductase 1… 
National Institutes of Health

Related topics

Related topics

5 relations
12q23-q24.1HomeostasisMetabolic Process, CellularOxidation-Reduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
The thioredoxin system in breast cancer cell invasion and migration
Highly Cited
2014
Highly Cited
2014
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo
Thioredoxin reductase (TrxR) is overpressed in many human tumors and has a key role in regulating intracellular redox balance… 
Review
2006
Review
2006
Mechanisms of iron-sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes.
Highly Cited
2006
Highly Cited
2006
Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells.
Certain selenoproteins such as GPX-1 (glutathione peroxidase-1) and TrxR1 (thioredoxin reductase-1) possess important antioxidant… 
Highly Cited
2006
Highly Cited
2006
Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1).
Highly Cited
2006
Highly Cited
2006
Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles.
Previous studies demonstrate that the covalent modification of thioredoxin reductase (TrxR) by both endogenous and exogenous… 
Highly Cited
2005
Highly Cited
2005
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF‐E2‐related factor‐2
Thioredoxin reductase (TrxR) is a selenoprotein that catalyzes the reduction of the active site disulfide of thioredoxin (Trx… 
Highly Cited
2003
Highly Cited
2003
The Mammalian Cytosolic Selenoenzyme Thioredoxin Reductase Reduces Ubiquinone
The selenoprotein thioredoxin reductase (TrxR1) is an essential antioxidant enzyme known to reduce many compounds in addition to… 
Highly Cited
1997
Highly Cited
1997
Regulation of potassium channels in coronary arterial smooth muscle by endothelium-derived vasodilators.
Recent studies have suggested that coronary endothelial cells produce and release nitric oxide (NO), prostaglandin I2, and… 
Highly Cited
1994
Highly Cited
1994
Excessive infant crying: a controlled study of mothers helping mothers.
OBJECTIVE To determine the efficacy of behavioral management counseling in the treatment of persistent, excessive infant crying… 
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