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TUBG1 protein, human

Known as: Gamma-1 Tubulin, Gamma Tubulin Polypeptide, Tubulin Gamma-1 Chain 
Expressed most in prophase through metaphase, during maximal microtubule assembly from centrosomes, by human TUBG1 Gene (Tubulin Family), ubiquitous… Expand
National Institutes of Health

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2019
2019
De novo heterozygous missense variants in the γ-tubulin gene TUBG1 have been linked to human malformations of cortical… Expand
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2016
2016
Adaptor protein (AP) complexes function in the intracellular sorting and vesicular transport of membrane proteins. The clathrin… Expand
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2014
2014
.................................................................................................................................. ii ACKNOWLEDGMENTS ........................................................................................................... iv LIST OF TABLES ..................................................................................................................... viii LIST OF FIGURES ..................................................................................................................... ix LIST OF APPENDICES .............................................................................................................. xi ABBREVIATIONS ..................................................................................................................... xii PROTEIN NAMES .................................................................................................................... xiv CHAPTER I: INTRODUCTION ............................................................................................... 1 1.1. The cell cycle ................................................................................................................................. 2 1.1.1. The basic principles of cell cycle regulation in eukaryotes .................................................... 2 1.1.2. The cell cycle and the centrosome cycle are intricately linked ............................................... 4 1.1.3. A network of kinases and phosphatases orchestrates mitotic processes ................................. 5 1.2. The centrosome ........................................................................................................................... 12 1.2.1. Centrosome functions and structure ...................................................................................... 12 1.2.2. The centrosome proteome ..................................................................................................... 13 1.2.3. Centrioles .............................................................................................................................. 14 1.2.3.1. Centriole architecture .................................................................................................................... 14 1.2.3.2. Centriole functions ........................................................................................................................ 15 1.2.4. The pericentriolar material (PCM) ........................................................................................ 16 1.2.5. The centrosome cycle ............................................................................................................ 25 1.2.5.1. Centriole duplication ..................................................................................................................... 25 1.2.5.2. Centrosome maturation and separation ......................................................................................... 28 1.3. The mitotic spindle ..................................................................................................................... 32 1.3.1. Microtubules are the basic elements of the mitotic spindle .................................................. 32 1.3.1.1. Astral microtubules regulate spindle positioning .......................................................................... 33 1.3.1.2. Interpolar microtubules fulfill important roles inside the mitotic spindle .................................... 34 1.3.1.3. Kinetochore microtubules are essential for chromosome segregation .......................................... 35 1.3.2. Microtubule nucleation pathways during mitotic spindle assembly ..................................... 37 1.3.2.1. RanGTP-dependent microtubule nucleation around chromatin .................................................... 38 1.3.2.2. CPC-dependent microtubule nucleation at kinetochores .............................................................. 39 1.3.2.3. Microtubule-dependent microtubule amplification within the spindle ......................................... 40 1.3.3. The role of mitotic motor and nonmotor proteins during spindle assembly ......................... 42 1.3.3.1. Mitotic motor proteins ................................................................................................................... 42 1.3.3.2. Nonmotor spindle proteins ............................................................................................................ 45 1.4. Spindle defects and human disease ........................................................................................... 49 1.4.1. Defects during spindle assembly can result in chromosome instability and aneuploidy ...... 49 1.4.2. Centrosomes are critical for asymmetric cell divisions during neurogenesis ....................... 52 1.5. Summary and rationale of my graduate work ........................................................................ 54 1.6. Figures ......................................................................................................................................... 56 
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2005
2005
Gamma-tubulin regulates the nucleation of microtubules, but knowledge of its functions in vivo is still fragmentary. Here, we… Expand
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2000
2000
Despite the central role of gamma-tubulin in the organization of the microtubule cytoskeleton, the gamma-tubulin gene family in… Expand
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Highly Cited
1995
Highly Cited
1995
The cysteine proteinase inhibitor, oryzacystatin-I (Oc-I), and several engineered Oc-I variants have been tested for efficacy in… Expand
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