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TSPAN12 gene

Known as: NET2, NET-2, TETRASPANIN 12 
 
National Institutes of Health

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TSPAN2 gene

Papers overview

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2017
2017
Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.
Purpose Familial exudative vitreoretinopathy (FEVR) is a severe hereditary retinal disorder characterized by defects in retinal… Expand
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2017
2017
TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling.
Accessory proteins in Frizzled (FZD) receptor complexes are thought to determine ligand selectivity and signaling amplitude… Expand
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2015
2015
Molecular Characterization of FZD4, LRP5, and TSPAN12 in Familial Exudative Vitreoretinopathy.
PURPOSE Familial exudative vitreoretinopathy (FEVR) is a rare hereditary disorder characterized by the failure of peripheral… Expand
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2014
2014
TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion.
Communication between cancer cells and their microenvironment controls cancer progression. Although the tumor suppressor p53… Expand
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2013
2013
Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation
Ablation of tetraspanin protein TSPAN12 from human MDA-MB-231 cells significantly decreased primary tumor xenograft growth, while… Expand
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2012
2012
Recessive mutations in TSPAN12 cause retinal dysplasia and severe familial exudative vitreoretinopathy (FEVR).
PURPOSE Familial exudative vitreoretinopathy (FEVR) is an inherited disorder that disrupts the development of the retinal… Expand
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2011
2011
Novel TSPAN12 mutations in patients with familial exudative vitreoretinopathy and their associated phenotypes
PURPOSE Mutations in tetraspanin 12 (TSPAN12) have recently been identified as a cause of autosomal dominant familial exudative… Expand
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Highly Cited
2010
Highly Cited
2010
Mutations in TSPAN12 cause autosomal-dominant familial exudative vitreoretinopathy.
Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder of the retinal vascular system. Although mutations… Expand
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Highly Cited
2009
Highly Cited
2009
TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling
Mutations in the genes encoding the Wnt receptor Frizzled-4 (FZD4), coreceptor LRP5, or the ligand Norrin disrupt retinal… Expand
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Highly Cited
2009
Highly Cited
2009
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein.
Using mass spectrometry, we identified ADAM10 (a membrane-associated metalloproteinase) as a partner for TSPAN12, a tetraspanin… Expand
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