TSC2 gene

Known as: TSC4, FORMERLY, tuberous sclerosis 2, Tuberous Sclerosis 2 Gene 
This gene plays a role in signal transduction and cell cycle control. It is involved in cell adhesion, differentiation, growth and migration.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
05101519932017

Papers overview

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Highly Cited
2010
Highly Cited
2010
PURPOSE We investigated the global gene expression in a large panel of pancreatic endocrine tumors (PETs) aimed at identifying… (More)
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Highly Cited
2006
Highly Cited
2006
The Kaposi's sarcoma-associated herpesvirus (KSHV), the infectious causative agent of Kaposi's sarcoma (KS), encodes a G protein… (More)
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2004
2004
Mutations in either TSC1 or TSC2 cause tuberous sclerosis complex, an autosomal dominant disorder characterized by seizures… (More)
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Highly Cited
2002
Highly Cited
2002
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that occurs upon mutation of either the TSC1 or TSC2… (More)
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Highly Cited
2002
Highly Cited
2002
Although the cellular functions of TSC2 and its protein product, tuberin, are not known, somatic mutations in the TSC2 tumor… (More)
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Highly Cited
2000
Highly Cited
2000
We report here that overexpression of the tuberous sclerosis-1 (TSC1) gene product hamartin results in the inhibition of growth… (More)
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Highly Cited
1999
Highly Cited
1999
  • T Kobayashi, O Minowa, J Kuno, H Mitani, Okio Hino, T Noda
  • Cancer research
  • 1999
Germ-line mutations of the human TSC2 tumor suppressor gene cause tuberous sclerosis (TSC), a disease characterized by the… (More)
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Highly Cited
1998
Highly Cited
1998
Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by a mutation in either the TSC1 or TSC2 tumour suppressor gene… (More)
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Highly Cited
1997
Highly Cited
1997
The tuberous sclerosis complex 2 (TSC2) is a tumor suppressor gene that plays a causative role in the autosomal dominant syndrome… (More)
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Highly Cited
1994
Highly Cited
1994
Genetic predisposition to neoplasia often involves tumor suppressor genes. One such model of hereditary renal carcinoma was… (More)
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