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TRAIL receptor activity

Known as: tumor necrosis factor-related apoptosis-inducing ligand receptor 
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
Recent evidences indicate that triple-negative breast cancer (TNBC) cells with a mesenchymal phenotype show a basal activation of… Expand
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2013
2013
Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells.
The herbal flavonoid quercetin inhibits the growth of various cancer cells, but how it affects human cancer cells, particularly… Expand
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Highly Cited
2010
Highly Cited
2010
Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors.
BACKGROUND Lexatumumab (HGS-ETR2) is a fully human agonistic mAb to the tumor necrosis factor-related apoptosis-inducing ligand… Expand
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Highly Cited
2010
Highly Cited
2010
Novel CSF biomarkers for frontotemporal lobar degenerations
Objective: To identify antemortem CSF diagnostic biomarkers that can potentially distinguish between the 2 main causes of… Expand
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2009
2009
SC68896, a Novel Small Molecule Proteasome Inhibitor, Exerts Antiglioma Activity In vitro and In vivo
Purpose: Glioblastomas are among the most lethal neoplasms, with a median survival of <1 year. Modulation of the proteasome… Expand
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Review
2007
Review
2007
Death receptor-mediated liver injury.
Apoptosis is a cardinal feature of liver injury. Death receptors are major mediators of the apoptotic pathway in the liver and… Expand
Highly Cited
2006
Highly Cited
2006
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Induction of tumor cell resistance to therapeutics has been a major obstacle in cancer therapy. Targeting of the death receptors… Expand
2006
2006
Death Receptor 4 Variants and Colorectal Cancer Risk
The tumor necrosis factor–related apoptosis-inducing ligand receptor modulates apoptotic response by binding to the proapoptotic… Expand
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2004
2004
Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumor but not normal cells, thus providing… Expand
Highly Cited
2002
Highly Cited
2002
Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells.
Studies with mouse embryo fibroblasts deficient for the BCL-2 family multidomain proapoptotic proteins BAX and BAK have revealed… Expand
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