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TRAIL receptor activity

Known as: tumor necrosis factor-related apoptosis-inducing ligand receptor 
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
Recent evidences indicate that triple-negative breast cancer (TNBC) cells with a mesenchymal phenotype show a basal activation of… 
2015
2015
Activation of KIT modulates the function of tumor necrosis factor‐related apoptosis‐inducing ligand receptor (TRAIL‐R) in mast cells
Mastocytosis is characterized by the accumulation of mast cells (MCs) associated with activating mutations of KIT. Tumor necrosis… 
2009
2009
Initial testing (stage 1) of mapatumumab (HGS‐ETR1) by the pediatric preclinical testing program
Mapatumumab (HGS‐ETR1) is a fully human IgG1 agonistic monoclonal antibody that exclusively targets and activates tumor necrosis… 
Review
2007
Review
2007
Death receptor-mediated liver injury.
Apoptosis is a cardinal feature of liver injury. Death receptors are major mediators of the apoptotic pathway in the liver and… 
2007
2007
Human agonistic antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 induces cytotoxicity and apoptosis in prostate cancer and bladder cancer cells.
Highly Cited
2006
Highly Cited
2006
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Induction of tumor cell resistance to therapeutics has been a major obstacle in cancer therapy. Targeting of the death receptors… 
Review
2005
Review
2005
Apoptosis-Inducing Anticancer Drugs in Clinical Trials
Apoptosis, or programmed cell death, plays an essential role in controlling cell number in many developmental and physiologic… 
2004
2004
Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes.
2002
2002
Combinations of antibodies selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and other therapeutic agents
The antibodies of the present invention shows a functional or antagonistic effects downstream of the receptor comprising a human… 
2002
2002
Combination of antibodies and other therapeutic agents selective for tumor necrosis factor-related apoptosis-inducing ligand receptor
The antibodies of the invention interact with human DR5 or human DR4 to produce agonist or antagonist effects downstream of the… 
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