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TRAIL receptor activity
Known as:
tumor necrosis factor-related apoptosis-inducing ligand receptor
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
Ana Cano-González
,
Marta Mauro-Lizcano
,
Daniel Iglesias-Serret
,
J. Gil
,
A. López-Rivas
Cell Death and Disease
2018
Corpus ID: 3716078
Recent evidences indicate that triple-negative breast cancer (TNBC) cells with a mesenchymal phenotype show a basal activation of…
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2015
2015
Activation of KIT modulates the function of tumor necrosis factor‐related apoptosis‐inducing ligand receptor (TRAIL‐R) in mast cells
A. Förster
,
S. Grotha
,
+9 authors
K. Hartmann
Allergy. European Journal of Allergy and Clinical…
2015
Corpus ID: 36802940
Mastocytosis is characterized by the accumulation of mast cells (MCs) associated with activating mutations of KIT. Tumor necrosis…
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Highly Cited
2013
Highly Cited
2013
Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells.
Hyesook Youn
,
Ji-Cheon Jeong
,
Youngjee Jeong
,
eun-joo kim
,
S. Um
Biological and Pharmaceutical Bulletin
2013
Corpus ID: 3750650
The herbal flavonoid quercetin inhibits the growth of various cancer cells, but how it affects human cancer cells, particularly…
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Highly Cited
2010
Highly Cited
2010
Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors.
H. Wakelee
,
A. Patnaik
,
+6 authors
A. Tolcher
Annals of Oncology
2010
Corpus ID: 23436414
BACKGROUND Lexatumumab (HGS-ETR2) is a fully human agonistic mAb to the tumor necrosis factor-related apoptosis-inducing ligand…
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2009
2009
SC68896, a Novel Small Molecule Proteasome Inhibitor, Exerts Antiglioma Activity In vitro and In vivo
P. Roth
,
M. Kissel
,
+4 authors
F. Schmidt
Clinical Cancer Research
2009
Corpus ID: 18741553
Purpose: Glioblastomas are among the most lethal neoplasms, with a median survival of <1 year. Modulation of the proteasome…
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2009
2009
Initial testing (stage 1) of mapatumumab (HGS‐ETR1) by the pediatric preclinical testing program
Malcolm A. Smith
,
C. Morton
,
+9 authors
P. Houghton
Pediatric Blood & Cancer
2009
Corpus ID: 37990937
Mapatumumab (HGS‐ETR1) is a fully human IgG1 agonistic monoclonal antibody that exclusively targets and activates tumor necrosis…
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Review
2007
Review
2007
Death receptor-mediated liver injury.
Y. Akazawa
,
G. Gores
Seminars in liver disease (Print)
2007
Corpus ID: 2412917
Apoptosis is a cardinal feature of liver injury. Death receptors are major mediators of the apoptotic pathway in the liver and…
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2007
2007
Human agonistic antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 induces cytotoxicity and apoptosis in prostate cancer and bladder cancer cells.
O. Shimada
,
Xiuxian Wu
,
+5 authors
Y. Kakehi
Urology
2007
Corpus ID: 20341613
Highly Cited
2006
Highly Cited
2006
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Yang Li
,
Hong Wang
,
+5 authors
T. Zhou
Cancer Research
2006
Corpus ID: 39787281
Induction of tumor cell resistance to therapeutics has been a major obstacle in cancer therapy. Targeting of the death receptors…
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2004
2004
Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes.
H. Hasegawa
,
Yasuaki Yamada
,
+7 authors
S. Kamihira
Cellular Immunology
2004
Corpus ID: 11250098
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