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TRAIL receptor activity
Known as:
tumor necrosis factor-related apoptosis-inducing ligand receptor
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
Ana Cano-González
,
Marta Mauro-Lizcano
,
D. Iglesias-Serret
,
J. Gil
,
A. López-Rivas
Cell Death and Disease
2018
Corpus ID: 3716078
Recent evidences indicate that triple-negative breast cancer (TNBC) cells with a mesenchymal phenotype show a basal activation of…
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Highly Cited
2013
Highly Cited
2013
Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells.
H. Youn
,
Ji-Cheon Jeong
,
Youngjee Jeong
,
eun-joo kim
,
S. Um
Biological and Pharmaceutical Bulletin
2013
Corpus ID: 3750650
The herbal flavonoid quercetin inhibits the growth of various cancer cells, but how it affects human cancer cells, particularly…
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Highly Cited
2010
Highly Cited
2010
Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors.
H. Wakelee
,
A. Patnaik
,
+6 authors
A. Tolcher
Annals of Oncology
2010
Corpus ID: 23436414
BACKGROUND Lexatumumab (HGS-ETR2) is a fully human agonistic mAb to the tumor necrosis factor-related apoptosis-inducing ligand…
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2009
2009
SC68896, a Novel Small Molecule Proteasome Inhibitor, Exerts Antiglioma Activity In vitro and In vivo
P. Roth
,
M. Kissel
,
+4 authors
F. Schmidt
Clinical Cancer Research
2009
Corpus ID: 18741553
Purpose: Glioblastomas are among the most lethal neoplasms, with a median survival of <1 year. Modulation of the proteasome…
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Review
2007
Review
2007
Death receptor-mediated liver injury.
Y. Akazawa
,
G. Gores
Seminars in liver disease (Print)
2007
Corpus ID: 2412917
Apoptosis is a cardinal feature of liver injury. Death receptors are major mediators of the apoptotic pathway in the liver and…
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2007
2007
Human agonistic antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 induces cytotoxicity and apoptosis in prostate cancer and bladder cancer cells.
O. Shimada
,
Xiu-xian Wu
,
+5 authors
Y. Kakehi
Urology
2007
Corpus ID: 20341613
Highly Cited
2006
Highly Cited
2006
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Yang Li
,
Hong Wang
,
+5 authors
T. Zhou
Cancer Research
2006
Corpus ID: 39787281
Induction of tumor cell resistance to therapeutics has been a major obstacle in cancer therapy. Targeting of the death receptors…
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2006
2006
Death Receptor 4 Variants and Colorectal Cancer Risk
B. Frank
,
K. S. Shanmugam
,
+5 authors
B. Burwinkel
Cancer Epidemiology, Biomarkers and Prevention
2006
Corpus ID: 1316581
The tumor necrosis factor–related apoptosis-inducing ligand receptor modulates apoptotic response by binding to the proapoptotic…
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Review
2005
Review
2005
Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents.
E. Rowinsky
Journal of Clinical Oncology
2005
Corpus ID: 469156
Targeted induction of programmed cell death or apoptosis via the extrinsic apoptotic pathway represents an unexploited…
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Highly Cited
2002
Highly Cited
2002
Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells.
P. Theodorakis
,
E. Lomonosova
,
G. Chinnadurai
Cancer Research
2002
Corpus ID: 15370699
Studies with mouse embryo fibroblasts deficient for the BCL-2 family multidomain proapoptotic proteins BAX and BAK have revealed…
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