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TRAIL receptor activity

Known as: tumor necrosis factor-related apoptosis-inducing ligand receptor 
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma… (More)

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Topic mentions per year

2001-2017
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TRAIL binding

Related mentions per year

Related mentions per year

1999-2017
1990200020102020
TRAIL receptor activity
TRAIL binding

Papers overview

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2008
2008
Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody.
BACKGROUND Resistance of tumors to cell death signals poses a complex clinical problem. We explored the therapeutic potential and… (More)
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2007
2007
Combined natural killer T-cell based immunotherapy eradicates established tumors in mice.
A rational monoclonal antibody (mAb)-based antitumor therapy approach has previously been shown to eradicate various established… (More)
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Highly Cited
2007
Highly Cited
2007
Phase 1 and pharmacokinetic study of lexatumumab in patients with advanced cancers.
PURPOSE To assess the safety and tolerability, pharmacokinetics, and early evidence of antitumor activity of escalating doses of… (More)
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2006
2006
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Induction of tumor cell resistance to therapeutics has been a major obstacle in cancer therapy. Targeting of the death receptors… (More)
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2006
2006
Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo…
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in a variety of tumor cells through two of its… (More)
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Highly Cited
2005
Highly Cited
2005
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.
While investigating the mechanism of action of the novel antitumor drug Aplidin, we have discovered a potent and novel cell… (More)
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2005
2005
Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer.
PURPOSE The cell surface receptors tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and TRAIL-R2… (More)
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2004
2004
Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces selective apoptosis in a variety of tumors, including… (More)
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2004
2004
Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD.
Members of the tumor necrosis factor superfamily of receptors induce apoptosis by recruiting adaptor molecules through death… (More)
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Highly Cited
2001
Highly Cited
2001
Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers.
Several lines of evidence suggest that apoptosis dysregulation plays an important role in cancer metastasis. In this study, to… (More)
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