TRAIL receptor activity

Known as: tumor necrosis factor-related apoptosis-inducing ligand receptor 
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma… (More)

Topic mentions per year

Topic mentions per year

2001-2017
024620012017

Papers overview

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2008
2008
BACKGROUND Resistance of tumors to cell death signals poses a complex clinical problem. We explored the therapeutic potential and… (More)
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2007
2007
A rational monoclonal antibody (mAb)-based antitumor therapy approach has previously been shown to eradicate various established… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE To assess the safety and tolerability, pharmacokinetics, and early evidence of antitumor activity of escalating doses of… (More)
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2006
2006
Induction of tumor cell resistance to therapeutics has been a major obstacle in cancer therapy. Targeting of the death receptors… (More)
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2006
2006
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in a variety of tumor cells through two of its… (More)
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Highly Cited
2005
Highly Cited
2005
While investigating the mechanism of action of the novel antitumor drug Aplidin, we have discovered a potent and novel cell… (More)
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2005
2005
PURPOSE The cell surface receptors tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and TRAIL-R2… (More)
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2004
2004
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces selective apoptosis in a variety of tumors, including… (More)
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2004
2004
Members of the tumor necrosis factor superfamily of receptors induce apoptosis by recruiting adaptor molecules through death… (More)
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Highly Cited
2001
Highly Cited
2001
Several lines of evidence suggest that apoptosis dysregulation plays an important role in cancer metastasis. In this study, to… (More)
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