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TRAIL receptor activity

Known as: tumor necrosis factor-related apoptosis-inducing ligand receptor 
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma… Expand
National Institutes of Health

Papers overview

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2013
2013
Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells.
The herbal flavonoid quercetin inhibits the growth of various cancer cells, but how it affects human cancer cells, particularly… Expand
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2010
2010
Novel CSF biomarkers for frontotemporal lobar degenerations(e–Pub ahead of print)
Objective:To identify antemortem CSF diagnostic biomarkers that can potentially distinguish between the 2 main causes of… Expand
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Highly Cited
2010
Highly Cited
2010
Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors.
BACKGROUND Lexatumumab (HGS-ETR2) is a fully human agonistic mAb to the tumor necrosis factor-related apoptosis-inducing ligand… Expand
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2009
2009
SC68896, a novel small molecule proteasome inhibitor, exerts antiglioma activity in vitro and in vivo.
PURPOSE Glioblastomas are among the most lethal neoplasms, with a median survival of <1 year. Modulation of the proteasome… Expand
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Review
2007
Review
2007
Death receptor-mediated liver injury.
Apoptosis is a cardinal feature of liver injury. Death receptors are major mediators of the apoptotic pathway in the liver and… Expand
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2007
2007
Human agonistic antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 induces cytotoxicity and apoptosis in prostate cancer and bladder cancer cells.
OBJECTIVES Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of tumor cells through… Expand
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2006
2006
Death receptor 4 variants and colorectal cancer risk.
The tumor necrosis factor-related apoptosis-inducing ligand receptor modulates apoptotic response by binding to the proapoptotic… Expand
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2006
2006
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Induction of tumor cell resistance to therapeutics has been a major obstacle in cancer therapy. Targeting of the death receptors… Expand
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2004
2004
Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumor but not normal cells, thus providing… Expand
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2002
2002
Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells.
Studies with mouse embryo fibroblasts deficient for the BCL-2 family multidomain proapoptotic proteins BAX and BAK have revealed… Expand
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