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TRA-8

National Institutes of Health

Papers overview

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2016
2016
A Novel Imaging Biomarker Extracted from Fluorescence Microscopic Imaging of TRA-8/DR5 Oligomers Predicts TRA-8 Therapeutic Efficacy in Breast and Pancreatic Cancer Mouse Models
PurposeThe aim of the study was to develop a reliable quantitative imaging biomarker from fluorescence microscopic imaging of TRA… 
2015
2015
Abstract 2931: Calmodulin-DR5 binding in breast cancer: Independent of TRA-8 sensitivity
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Breast cancer is estimated to be the leading… 
2014
2014
Abstract 2268: Augmentation of DR5 expression by calmodulin antagonists sensitizes TRA-8-induced apoptosis in pancreatic cancer
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Pancreatic cancer is the fourth leading cause of cancer… 
2013
2013
Abstract 2955: Effect of the combined treatment of TRA-8, an agonistic DR5 antibody, and tamoxifen on breast cancer cells.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Breast cancer affects an estimated 1.3 million women… 
2013
2013
Abstract 2947: PARP-1 regulates death receptor 5-mediated apoptosis in pancreatic cancer.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Pancreatic cancer is a highly malignant tumor with… 
2012
2012
Ultrasound imaging of whole tumor response to drug therapy
Use of volumetric contrast-enhanced ultrasound (US) imaging of cancer-bearing mice allows description of whole tumor perfusion… 
2011
2011
Sensitization of glioma to death receptor 5-mediated apoptosis through genotoxic stress and cell cycle disruption: A study of mechanism
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2009
2009
Cytotoxicity and radiosensitization effect of TRA-8 on radioresistant human larynx squamous carcinoma cells.
TRAIL induces apoptosis in a variety of tumorigenic and transformed cell lines, but not in many normal cells. Recent studies have… 
2008
2008
Effect of TRA-8 anti-DR5 monoclonal antibody in combination with chemotherapy in an ex vivo human ovarian cancer model
14695 Background: It has been previously demonstrated that TRA-8 anti-DR5 monoclonal antibody induces apoptosis in primary human… 
2005
2005
TRAIL death receptor therapy for malignant glioma
3187 Purpose: To evaluate the in vivo efficacy of a novel proapoptotic mouse monoclonal antibody, TRA-8, which binds to death… 
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