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TPA 023

Known as: TPA-023, TPA023 
 
National Institutes of Health

Papers overview

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Review
2013
Review
2013
GAB(A) (γ-aminobutyric acid) is abundantly expressed within the brain, and spinal cord pain circuits where it acts as the… Expand
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2013
2013
Temporary neuronal inactivation of the ventral hippocampus with the GABAA agonist muscimol suppresses unconditioned fear behavior… Expand
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Review
2012
Review
2012
In the regulation of behavior, the role of GABA neurons has been extensively studied in the circuit of fear, where GABA… Expand
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Review
2012
Review
2012
  • Phil Skolnick
  • Trends in pharmacological sciences
  • 2012
  • Corpus ID: 13932634
The discovery of benzodiazepine receptors provided the impetus to discover and develop anxioselective anxiolytics ('Valium… Expand
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Review
2011
Review
2011
  • John R Atack
  • Current topics in medicinal chemistry
  • 2011
  • Corpus ID: 37882457
The prototypic benzodiazepines, such as diazepam, are not only anxiolytic but also produce sedation. These effects are mediated… Expand
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2011
2011
After injury GABA(A) receptor positive allosteric modulators (PAMs) mediate robust analgesia in animals via putative restoration… Expand
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Review
2010
Review
2010
  • John R Atack
  • Current topics in behavioral neurosciences
  • 2010
  • Corpus ID: 8801790
Nonselective benzodiazepines exert their pharmacological effects via GABAA receptors containing either an alpha1, alpha2, alpha3… Expand
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2010
2010
Abuse-liability-related effects of subtype-selective GABA(A) modulators were explored relative to the prototypic benzodiazepine… Expand
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Review
2009
Review
2009
The use of genetically-engineered mice has identified alpha2- and alpha3-subunit containing GABA(A) receptors as principal… Expand
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Review
2009
Review
2009
TPA023 is a GABA(A) alpha2/alpha3 subtype-selective modulator which in preclinical species has anxiolytic-like activity but does… Expand
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