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TPA 023

Known as: TPA-023, TPA023 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
  • H. Möhler
  • Neuropharmacology
  • 2012
  • Corpus ID: 23950328
In the regulation of behavior, the role of GABA neurons has been extensively studied in the circuit of fear, where GABA… Expand
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Review
2012
Review
2012
  • P. Skolnick
  • Trends in pharmacological sciences
  • 2012
  • Corpus ID: 13932634
The discovery of benzodiazepine receptors provided the impetus to discover and develop anxioselective anxiolytics ('Valium… Expand
Review
2011
Review
2011
  • J. Atack
  • Current topics in medicinal chemistry
  • 2011
  • Corpus ID: 37882457
The prototypic benzodiazepines, such as diazepam, are not only anxiolytic but also produce sedation. These effects are mediated… Expand
2011
2011
After injury GABA(A) receptor positive allosteric modulators (PAMs) mediate robust analgesia in animals via putative restoration… Expand
2010
2010
BACKGROUND Ketamine has been used to model cognitive and behavioral symptoms of schizophrenia. Current hypotheses state that… Expand
Review
2009
Review
2009
The use of genetically-engineered mice has identified alpha2- and alpha3-subunit containing GABA(A) receptors as principal… Expand
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Review
2009
Review
2009
  • J. Atack
  • Advances in pharmacology
  • 2009
  • Corpus ID: 24734744
TPA023 is a GABA(A) alpha2/alpha3 subtype-selective modulator which in preclinical species has anxiolytic-like activity but does… Expand
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Review
2008
Review
2008
  • J. Atack
  • CNS neuroscience & therapeutics
  • 2008
  • Corpus ID: 2328179
TPA023 and α5IA are structurally related compounds that selectively modulate certain GABAA receptor subtypes. Hence, TPA023 has… Expand
Highly Cited
2007
Highly Cited
2007
TPA023, a GABAA α2,3 αsubtype-selective partial agonist, is expected to have comparable anxiolytic efficacy as benzodiazepines… Expand
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Highly Cited
2006
Highly Cited
2006
7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) is a… Expand