TP53BP1 protein, human

Known as: p53-Binding Protein 1, 53BP1, p202 protein, human 
Tumor suppressor p53-binding protein 1 (1972 aa, ~214 kDa) is encoded by the human TP53BP1 gene. This protein may play a role in nonhomologous end… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2017
0102019942017

Papers overview

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Highly Cited
2013
Highly Cited
2013
BRCA1 promotes homologous recombination repair and antagonizes 53BP1-dependent nonhomologous end joining (NHEJ) pathway. However… (More)
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Highly Cited
2013
Highly Cited
2013
The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by… (More)
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Highly Cited
2008
Highly Cited
2008
Double-strand breaks activate the ataxia telangiectasia mutated (ATM) kinase, which promotes the accumulation of DNA damage… (More)
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Highly Cited
2007
Highly Cited
2007
MDC1 and 53BP1 are critical components of the DNA damage response (DDR) machinery that protects genome integrity and guards… (More)
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Highly Cited
2006
Highly Cited
2006
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… (More)
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Highly Cited
2005
Highly Cited
2005
53BP1 is a key component of the genome surveillance network activated by DNA double strand breaks (DSBs). Despite its known… (More)
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Highly Cited
2004
Highly Cited
2004
53BP1 participates early in the DNA damage response and is involved in cell cycle checkpoint control. Moreover, the phenotype of… (More)
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Highly Cited
2003
Highly Cited
2003
53BP1 participates in the cellular response to DNA damage. Like many proteins involved in the DNA damage response, 53BP1 becomes… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR… (More)
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Highly Cited
2001
Highly Cited
2001
The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of p53 and enhances p53-mediated… (More)
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