FAQ

TP53BP1 protein, human

Known as: p53-Binding Protein 1, 53BP1, p202 protein, human 
Tumor suppressor p53-binding protein 1 (1972 aa, ~214 kDa) is encoded by the human TP53BP1 gene. This protein may play a role in nonhomologous end… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2017
0102019942017

Related topics

Related topics

8 relations
Cell Cycle ControlDNA RepairGenes, RegulatorGenes, cdc
(More)

Broader (2)

TP53BP1 wt AlleleTumor Suppressor p53-Binding Protein 1

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
TP53BP1 protein, human
DNA Repair
regulatory proteins
Cell Cycle Control
Genes, Regulator
Genes, cdc

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
RIF1 counteracts BRCA1-mediated end resection during DNA repair.
BRCA1 promotes homologous recombination repair and antagonizes 53BP1-dependent nonhomologous end joining (NHEJ) pathway. However… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2013
Highly Cited
2013
53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions
The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
Double-strand breaks activate the ataxia telangiectasia mutated (ATM) kinase, which promotes the accumulation of DNA damage… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
MDC1 and 53BP1 are critical components of the DNA damage response (DDR) machinery that protects genome integrity and guards… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
53BP1 is a key component of the genome surveillance network activated by DNA double strand breaks (DSBs). Despite its known… (More)
  • figure 1
  • figure 2
  • figure 3
  • table I
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
53BP1 is required for class switch recombination
53BP1 participates early in the DNA damage response and is involved in cell cycle checkpoint control. Moreover, the phenotype of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.
53BP1 participates in the cellular response to DNA damage. Like many proteins involved in the DNA damage response, 53BP1 becomes… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1
Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways
The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of p53 and enhances p53-mediated… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?