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TP53BP1 protein, human

Known as: p53-Binding Protein 1, 53BP1, p202 protein, human 
Tumor suppressor p53-binding protein 1 (1972 aa, ~214 kDa) is encoded by the human TP53BP1 gene. This protein may play a role in nonhomologous end… 
National Institutes of Health

Related topics

Related topics

8 relations
Cell Cycle ControlDNA RepairGenes, RegulatorGenes, cdc

Broader (2)

TP53BP1 wt AlleleTumor Suppressor p53-Binding Protein 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
53BP1 Sensitizes Breast Cancer Cells to 5-Fluorouracil
Chemoresistance of breast cancer is a worldwide problem for breast cancer and the resistance to chemotherapeutic agents… 
2012
2012
Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability
Cell cycle regulation and DNA repair following damage are essential for maintaining genome integrity. DNA damage activates… 
2011
2011
Protein-Protein Interactions Occur Between p53 Phosphoforms and ATM and 53BP1 at Sites of Exogenous DNA Damage
Abstract We have previously shown that the Ser15-phosphorylated p53 phosphoform, p53Ser15, can localize at sites of ionizing… 
2011
2011
Genetic polymorphisms and cervical cancer development: ATM G5557A and p53bp1 C1236G
Persistent infections by high-risk types of human papillomavirus (HPV) have been established as the etiological agent of cervical… 
Review
2010
Review
2010
The interplay between BRCA1 and 53BP1 influences death, aging, senescence and cancer.
Highly Cited
2008
Highly Cited
2008
RNF8-dependent and RNF8-independent Regulation of 53BP1 in Response to DNA Damage*
The DNA damage surveillance network orchestrates cellular responses to DNA damage through the recruitment of DNA damage-signaling… 
2007
2007
[Correlation of 53BP1 and p53 polymorphisms to susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma].
BACKGROUND & OBJECTIVE 53BP1 is one of p53-binding proteins, which can enhance the transcriptional activation of p53 and plays a… 
Highly Cited
2006
Highly Cited
2006
E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts
Deregulation of the Rb/E2F pathway in human fibroblasts results in an E2F1-mediated apoptosis dependent on Atm, Nbs1, Chk2 and… 
2006
2006
Stage specific expression of histone deacetylase 4 (HDAC4) during oogenesis and early preimplantation development in mice.
Oogenesis is a critical event in the formation of gametes, which transfer genomic information to the next generation. During this… 
2005
2005
Jun activation domain-binding protein 1 is required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1
Purpose: p53-binding protein 1 (53BP1), a participant in the DNA damage response pathway, has also been implicated in the… 
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