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TP53 wt Allele

Known as: p53 gene, P53, TRP53 
Human TP53 wild-type allele is located in the vicinity of 17p13.1 and is approximately 19 kb in length. This allele, which encodes cellular tumor… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
  • K. Beyfuss, D. Hood
  • Redox report : communications in free radical…
  • 2018
  • Corpus ID: 12599412
ABSTRACT Background: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53… Expand
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Highly Cited
2016
Highly Cited
2016
Mutations disabling the TP53 tumour suppressor gene represent the most frequent events in human cancer and typically occur… Expand
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Highly Cited
2014
Highly Cited
2014
RUNX1 encodes a RUNX family transcription factor (TF) and was recently identified as a novel mutated gene in human luminal breast… Expand
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Most personalized cancer care strategies involving DNA sequencing are highly reliant on acquiring sufficient fresh or… Expand
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Highly Cited
2013
Highly Cited
2013
Anticancer chemotherapy drugs challenge hematopoietic tissues to regenerate but commonly produce long-term sequelae. Chemotherapy… Expand
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Highly Cited
2009
Highly Cited
2009
We screened exon 4 of the gene isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) for mutations in 596 primary intracranial… Expand
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Highly Cited
2009
Highly Cited
2009
Trp53 loss of function has previously been shown to rescue tissue maintenance and developmental defects resulting from DNA damage… Expand
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Highly Cited
2007
Highly Cited
2007
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. HCC patients frequently present with disease… Expand
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Highly Cited
2004
Highly Cited
2004
Astrocytoma is the most common malignant brain tumor in humans. Loss of the p53 signaling pathway and up-regulation of the ras… Expand
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Highly Cited
2003
Highly Cited
2003
The application of RNA interference (RNAi) to mammalian systems has the potential to revolutionize genetics and produce novel… Expand
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