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TP53 Gene Mutation

Known as: p53 Mutation 
A change in the nucleotide sequence of the TP53 gene.
National Institutes of Health

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Related topics

3 relations
High Grade Ovarian Serous AdenocarcinomaSerous Tubal Intraepithelial CarcinomaTP53 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas from head and neck
To investigate the response of tumour growth to cisplatin treatment, in relation to p53 mutation and cyclin D1 dysregulation on… 
Highly Cited
2003
Highly Cited
2003
Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types.
Highly Cited
2000
Highly Cited
2000
Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer.
Previous studies have determined that the frequency of germ-line p53 mutations in familial breast cancer patients is 1% or less… 
Review
2000
Review
2000
p53 mutations in epithelial ovarian cancers: possible role in predicting chemoresistance.
PURPOSE The investigators undertook a retrospective study to determine (1) whether p53 mutations are predictors of survival in… 
2000
2000
Relationship between p53 gene mutation and protein expression: clinical significance in transitional cell carcinoma of the bladder.
Although the mutated p53 gene has been postulated to induce immunohistochemically-detectable p53 protein, reports regarding the… 
Highly Cited
1997
Highly Cited
1997
p53 mutation as a prognostic marker in advanced laryngeal carcinoma. Department of Veterans Affairs Laryngeal Cancer Cooperative Study Group.
OBJECTIVE To determine the relationship of p53 mutations in advanced laryngeal carcinomas to p53 immunohistochemistry, organ… 
Highly Cited
1996
Highly Cited
1996
The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein.
MDM2 gene overexpression has been implicated in the pathogenesis of human neoplasia via inhibition of the p53 tumor-suppressor… 
Highly Cited
1995
Highly Cited
1995
Constitutional p53 mutations associated with brain tumors in young adults.
Highly Cited
1995
Highly Cited
1995
p53 mutations and prognosis in bladder tumors.
1992
1992
Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.
Germline p53 mutations have been identified in the Li-Fraumeni syndrome but the role of such mutations in familial leukemia is… 
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