TNFSF10 protein, human

Known as: TNFSF10 Protein, TRAIL, Apo-2L 
Tumor necrosis factor ligand superfamily member 10 (281 aa, ~33 kDa) is encoded by the human TNFSF10 gene. This protein plays a role in the induction… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Apoptosis-inducing ligand 2 (Apo2L), also called tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), triggers… (More)
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Highly Cited
2004
Highly Cited
2004
Present studies demonstrate that treatment with the histone deacetylases inhibitor LAQ824, a cinnamic acid hydroxamate, increased… (More)
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Highly Cited
2002
Highly Cited
2002
A major concern in cancer therapy is resistance of tumors such as glioblastoma to current treatment protocols. Here, we report… (More)
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Highly Cited
2002
Highly Cited
2002
The importance of Bax for induction of tumor apoptosis through death receptors remains unclear. Here we show that Bax can be… (More)
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Highly Cited
2002
Highly Cited
2002
Interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) promote the proliferation of multiple myeloma (MM) cells and… (More)
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Highly Cited
2001
Highly Cited
2001
We have demonstrated that Apo-2 ligand (Apo-2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis… (More)
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Highly Cited
1999
Highly Cited
1999
TNF and Fas ligand induce apoptosis in tumor cells; however, their severe toxicity toward normal tissues hampers their… (More)
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Highly Cited
1999
Highly Cited
1999
Formation of a complex between Apo2L (also called TRAIL) and its signaling receptors, DR4 and DR5, triggers apoptosis by inducing… (More)
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Highly Cited
1998
Highly Cited
1998
APO2L (TRAIL) is a novel CD95L (Fas/APO-1-L) homologous cytotoxic cytokine that interacts with various receptors which transmit… (More)
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Highly Cited
1997
Highly Cited
1997
A novel (TL1), a recently described (TL2) TNF-like, and three recently described TNF receptor-like (TR1, TR2, TR3) molecules were… (More)
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