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TNFAIP3 protein, human

Known as: OTU Domain-Containing Protein 7C, tumor necrosis factor, alpha-induced protein 3, human, Putative DNA-Binding Protein A20 
Tumor necrosis factor alpha-induced protein 3 (790 aa, ~90 kDa) is encoded by the human TNFAIP3 gene. This protein may play a role in the regulation… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Functional characterization of causal variants present on risk haplotypes identified through genome-wide association studies… Expand
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Review
2012
Review
2012
A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts multiple intracellular signalling… Expand
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Highly Cited
2012
Highly Cited
2012
Constitutive activation of the NF-κB pathway is associated with diffuse large B-cell lymphoma (DLBCL) pathogenesis, but whether… Expand
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Highly Cited
2012
Highly Cited
2012
Background: Macrophages that respond to external stimuli assume a spectrum of activation states. Results: Expression of several… Expand
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Highly Cited
2012
Highly Cited
2012
The TNFAIP3 gene has been associated with psoriasis, rheumatoid arthritis, type 1 diabetes mellitus, systemic lupus erythematosus… Expand
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Highly Cited
2011
Highly Cited
2011
Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized by self-reactive antibodies resulting in… Expand
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Highly Cited
2011
Highly Cited
2011
Recent studies have revealed that microRNA-29c (miR-29c) is involved in a variety of biological processes including… Expand
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Highly Cited
2010
Highly Cited
2010
Background TNFAIP3 encodes the ubiquitin-modifying enzyme, a key regulator of inflammatory signalling pathways. Convincing… Expand
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Review
2009
Review
2009
Nuclear factor (NF)-kappaB has an important role in immunity and inappropriate NF-kappaB activity has been linked with many… Expand
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Highly Cited
2008
Highly Cited
2008
The TNFAIP3 (tumor necrosis factor alpha–induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-κB… Expand
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