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Human cytomegalovirus (HCMV) can persistently infect humans, but how HCMV avoids humoral immunity is not clear. The neonatal Fc… Expand Misfolded proteins from the endoplasmic reticulum (ER) are transported back into the cytosol for degradation via the ubiquitin… Expand Background: SNP rs798766 within the 4p16.3 region was associated with bladder cancer risk in several GWAS. This SNP is located… Expand Highlights • E3 ubiquitin ligases play a central role in viral and cellular degradation of MHC-I.• HCMV US2 and US11 hijack the… Expand Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA
Genome-wide association studies (GWAS) have… Expand Misfolded ER proteins are retrotranslocated into the cytosol for degradation via the ubiquitin–proteasome system. The human… Expand Significance Newly synthesized proteins undergo a strict quality-control checkpoint, and misfolded secretory proteins are… Expand