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TMEM127 gene

Known as: TRANSMEMBRANE PROTEIN 127, Transmembrane Protein 127 Gene, TMEM127 
This gene may play a role in signaling and protein trafficking.
National Institutes of Health

Related topics

Related topics

3 relations
Inhibition of Cell ProliferationSignal TransductionSignal Transduction Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention
Importance Effective cancer prevention is based on accurate molecular diagnosis and results of genetic family screening, genotype… Expand
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2015
2015
Penetrance and clinical features of pheochromocytoma in a six-generation family carrying a germline TMEM127 mutation.
CONTEXT The phenotype of familial pheochromocytoma (PHEO) associated with germline TMEM127 mutations (TMEM127-related PHEO) has… Expand
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Highly Cited
2014
Highly Cited
2014
Rare germline mutations identified by targeted next-generation sequencing of susceptibility genes in pheochromocytoma and paraganglioma.
CONTEXT Pheochromocytomas and paragangliomas have a highly diverse genetic background, with a third of the cases carrying a… Expand
Is this relevant?
2014
2014
The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function.
TMEM127 is an endosome-associated tumor suppressor gene in pheochromocytomas, neuroendocrine tumors that can co-occur with renal… Expand
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2012
2012
TMEM127 screening in a large cohort of patients with pheochromocytoma and/or paraganglioma.
CONTEXT TMEM127 is a novel pheochromocytoma (PCC) susceptibility gene. OBJECTIVES Our aim was to clearly determine the… Expand
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Highly Cited
2012
Highly Cited
2012
Somatic NF1 inactivation is a frequent event in sporadic pheochromocytoma.
Germline mutations in the RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, MAX, TMEM127, NF1 or VHL genes are identified in about 30% of… Expand
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Highly Cited
2011
Highly Cited
2011
Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma.
Pheochromocytomas and paragangliomas are neuroendocrine tumors that occur in the context of inherited cancer syndromes in ∼30% of… Expand
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Highly Cited
2011
Highly Cited
2011
Germline mutations of the TMEM127 gene in patients with paraganglioma of head and neck and extraadrenal abdominal sites.
BACKGROUND Hereditary pheochromocytoma is associated with germline mutations of a set of susceptibility genes to which the… Expand
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Germline mutations in TMEM127 confer susceptibility to pheochromocytoma
Pheochromocytomas, which are catecholamine-secreting tumors of neural crest origin, are frequently hereditary. However, the… Expand
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Highly Cited
2010
Highly Cited
2010
Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas.
CONTEXT Pheochromocytomas and paragangliomas are genetically heterogeneous neural crest-derived neoplasms. We recently identified… Expand
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