FAQ

TMEM127 gene

Known as: TRANSMEMBRANE PROTEIN 127, Transmembrane Protein 127 Gene, TMEM127 
This gene may play a role in signaling and protein trafficking.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2018
05101520102018

Related topics

Related topics

4 relations
Inhibition of Cell ProliferationSignal TransductionSignal Transduction InhibitionTransmembrane Protein 127

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
TMEM127 gene
Signal Transduction
Inhibition of Cell Proliferation
Signal Transduction Inhibition
Transmembrane Protein 127

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Penetrance and clinical features of pheochromocytoma in a six-generation family carrying a germline TMEM127 mutation.
CONTEXT The phenotype of familial pheochromocytoma (PHEO) associated with germline TMEM127 mutations (TMEM127-related PHEO) has… (More)
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2014
2014
The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function.
TMEM127 is an endosome-associated tumor suppressor gene in pheochromocytomas, neuroendocrine tumors that can co-occur with renal… (More)
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2012
2012
Identical germline mutations in the TMEM127 gene in two unrelated Japanese patients with bilateral pheochromocytoma.
OBJECTIVE Recently, TMEM127 was shown to be a new pheochromocytoma susceptibility gene; this is consistent with its function as a… (More)
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2012
2012
TMEM127 screening in a large cohort of patients with pheochromocytoma and/or paraganglioma.
CONTEXT TMEM127 is a novel pheochromocytoma (PCC) susceptibility gene. OBJECTIVES Our aim was to clearly determine the… (More)
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2011
2011
Germline mutations of the TMEM127 gene in patients with paraganglioma of head and neck and extraadrenal abdominal sites.
BACKGROUND Hereditary pheochromocytoma is associated with germline mutations of a set of susceptibility genes to which the… (More)
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2011
2011
A novel TMEM127 mutation in a patient with familial bilateral pheochromocytoma.
OBJECTIVE In this report, we describe a new patient with unexplained familial bilateral pheochromocytoma. Following the recent… (More)
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Highly Cited
2011
Highly Cited
2011
Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma.
Pheochromocytomas and paragangliomas are neuroendocrine tumors that occur in the context of inherited cancer syndromes in ∼30% of… (More)
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2011
2011
Is genetic screening indicated in apparently sporadic pheochromocytomas and paragangliomas?
BACKGROUND Pheochromocytoma (Pheo) is usually considered a sporadic disease. Recently, an increasing rate of genetically based… (More)
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Highly Cited
2010
Highly Cited
2010
Germline mutations in TMEM127 confer susceptibility to pheochromocytoma
Pheochromocytomas, which are catecholamine-secreting tumors of neural crest origin, are frequently hereditary. However, the… (More)
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Highly Cited
2010
Highly Cited
2010
Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas.
CONTEXT Pheochromocytomas and paragangliomas are genetically heterogeneous neural crest-derived neoplasms. We recently identified… (More)
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