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TJ0711

National Institutes of Health

Papers overview

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2018
2018
Accurate determination of a novel vasodilatory β-blocker TJ0711 using LC-MS/MS: Resolution of an isobaric metabolite interference in dog plasma.
A rapid, robust and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for bioanalysis… 
2017
2017
Enantioselective determination of 1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol hydrochloride, a novel antihypertensive agent, in rat plasma and tissues by liquid…
Enantioselective biodistribution studies of 1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol… 
2015
2015
Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass…
TJ0711 (1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol) is a novel β-adrenoreceptor blocker with… 
2014
2014
[Antiarrhythmic effect of TJ0711].
To study the antiarrhythmic effect of the newly developed alpha/beta-blocker TJ0711, a variety of animal models of arrhythmia… 
2013
2013
TJ0711, a novel vasodilatory β-blocker, protects SHR rats against hypertension induced renal injury.
Previous studies suggested that β-blockers with adjunctive α1-blocking activities warrant renoprotective function other than the… 
2012
2012
[Pharmacodynamic study of racemic TJ0711 on renal hypertensive rats after long-term administration].
The study is to observe the effect of racemic TJ0711 on blood pressure and heart rate as well as protection of cardiovascular… 
2012
2012
In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method.
2009
2009
Stereoselective HPLC Assay of TJ 0711 Enantiomers by Precolumn Derivatization with GITC Using UV Detection and Its Application in Pharmacokinetics in Rats *
This investigation describes a new precise, sensitive and accurate stereoselective RP-HPLC method for determination of the… 
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