TIRAP gene

Known as: TIRAP, wyatt, MYD88 ADAPTOR-LIKE 
 
National Institutes of Health

Papers overview

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Review
2007
Review
2007
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Signalling by Toll-like receptors (TLRs) involves five adaptor proteins known as MyD88, MAL, TRIF, TRAM and SARM. Recent insights… (More)
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Highly Cited
2007
Highly Cited
2007
Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.
Actin, which is best known as a cytoskeletal component, also participates in the control of gene expression. We report a function… (More)
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Highly Cited
2006
Highly Cited
2006
Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling
Toll-like receptors (TLRs) play a critical role in the immune system as sensors of microbial infection. Signaling downstream from… (More)
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Review
2005
Review
2005
Toll-like receptors in innate immunity.
Functional characterization of Toll-like receptors (TLRs) has established that innate immunity is a skillful system that detects… (More)
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Review
2004
Review
2004
TLR signaling pathways.
Toll-like receptors (TLRs) have been established to play an essential role in the activation of innate immunity by recognizing… (More)
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Highly Cited
2003
Highly Cited
2003
Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL
Rho GTPases regulate the transcription factor SRF via their ability to induce actin polymerization. SRF activity responds to G… (More)
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Highly Cited
2003
Highly Cited
2003
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction
Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)-β independent of… (More)
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Highly Cited
2002
Highly Cited
2002
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
Signal transduction through Toll-like receptors (TLRs) originates from their intracellular Toll/interleukin-1 receptor (TIR… (More)
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Highly Cited
2002
Highly Cited
2002
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
Mammalian Toll-like receptors (TLRs) function as sensors of infection and induce the activation of innate and adaptive immune… (More)
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Highly Cited
2001
Highly Cited
2001
TIRAP: an adapter molecule in the Toll signaling pathway
Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-κB and other signaling… (More)
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