TIGIT gene

Known as: FLJ39873, DKFZp667A205, TIGIT 
This gene is involved in cell-cell adhesion and the regulation of T-cell and dendritic cell activity.

Topic mentions per year

Topic mentions per year

2009-2017
0204020092017

Papers overview

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Highly Cited
2015
Highly Cited
2015
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NK cells. Here, we… (More)
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Highly Cited
2015
Highly Cited
2015
Bacteria, such as Fusobacterium nucleatum, are present in the tumor microenvironment. However, the immunological consequences of… (More)
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Highly Cited
2014
Highly Cited
2014
Foxp3(+) T regulatory (Treg) cells regulate immune responses and maintain self-tolerance. Recent work shows that Treg cells are… (More)
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Highly Cited
2014
Highly Cited
2014
Tumors constitute highly suppressive microenvironments in which infiltrating T cells are "exhausted" by inhibitory receptors such… (More)
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Highly Cited
2013
Highly Cited
2013
Recurrent solid malignancies are often refractory to standard therapies. Although adoptive T cell transfer may benefit select… (More)
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2013
2013
The activity of natural killer (NK) cells is controlled by a balance of signals derived from inhibitory and activating receptors… (More)
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2012
2012
T cell Ig and ITIM domain (TIGIT) is a newly identified receptor expressed on T cells that binds to CD155 on the dendritic cell… (More)
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Highly Cited
2011
Highly Cited
2011
Costimulatory molecules regulate the functional outcome of T cell activation, and disturbance of the balance between activating… (More)
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Highly Cited
2009
Highly Cited
2009
Here we have identified a surface protein, TIGIT, containing an immunoglobulin variable domain, a transmembrane domain and an… (More)
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Highly Cited
2009
Highly Cited
2009
NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC… (More)
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