FAQ

TIAM1 Protein

Known as: T-Lymphoma Invasion and Metastasis Inducing Protein 1, TIAM1 
TIAM1 appears to function in cellular signaling by modulating activation the GDP-GTP exchange activity of RHO-like GTPases that regulate cytoskeletal… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2016
0246819952016

Related topics

Related topics

5 relations
BrainSignal TransductionSignaling Pathway GeneTIAM1 gene
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
TIAM1 Protein
Signal Transduction
Brain
Testis
TIAM1 gene
Signaling Pathway Gene

Papers overview

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2015
2015
By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth
Gastric cancer (GC) is one of the most common malignant tumors worldwide. Emerging evidence has shown that abnormal microRNAs… (More)
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2015
2015
HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion
The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor formation. Here, we uncover a role for… (More)
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2014
2014
TIAM1–RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy
In diabetes, increased retinal oxidative stress is seen before the mitochondria are damaged. Phagocyte-like NADPH oxidase-2 (NOX2… (More)
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2013
2013
MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma.
Based on microarray analysis, we previously reported that miR-29c is significantly downregulated in nasopharyngeal carcinoma (NPC… (More)
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2013
2013
miRNA-218 inhibits osteosarcoma cell migration and invasion by down-regulating of TIAM1, MMP2 and MMP9.
Deregulated miRNAs participate in osteosarcoma genesis. In this study, the expression of miRNA-218 in human osteosarcomas… (More)
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Highly Cited
2010
Highly Cited
2010
miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells.
TGF-β promotes cell migration and invasion, an attribute that is linked to the pro-metastasis function of this cytokine in late… (More)
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2010
2010
Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).
The Rac exchange factor Tiam1 is involved in diverse cell functions and signaling pathways through multiple protein interactions… (More)
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Highly Cited
2006
Highly Cited
2006
The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis
PAR-3 (partitioning-defective gene 3) is essential for cell polarization in many contexts, including axon specification. However… (More)
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2006
2006
Molecular detection of circulating cancer cells in the peripheral blood of patients with colorectal cancer by using membrane array with a multiple mRNA marker panel.
The objective of this study was mainly to evaluate the simultaneous detection of expression levels of a multiple mRNA marker… (More)
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1995
1995
Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin.
By means of proviral tagging in combination with in vitro selection for invasive T-lymphoma variants, we have previously… (More)
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