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TIAM1 Protein

Known as: T-Lymphoma Invasion and Metastasis Inducing Protein 1, TIAM1 
TIAM1 appears to function in cellular signaling by modulating activation the GDP-GTP exchange activity of RHO-like GTPases that regulate cytoskeletal… 
National Institutes of Health

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BrainSignal TransductionSignaling Pathway GeneTIAM1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
miRNA-218 inhibits osteosarcoma cell migration and invasion by down-regulating of TIAM1, MMP2 and MMP9.
Deregulated miRNAs participate in osteosarcoma genesis. In this study, the expression of miRNA-218 in human osteosarcomas… 
Highly Cited
2010
Highly Cited
2010
Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation.
2009
2009
Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1.
In this study, we investigated the expression level of Ras-homologous (Rho) GTPases and the Rho guanine exchange factor (GEF) T… 
2008
2008
Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation.
The lethality of pancreatic adenocarcinoma stems from an elevated incidence of tumor cell invasion and metastasis that are… 
Review
2006
Review
2006
Wnt signalling in the mouse intestine
The ApcMin/+ mouse has emerged as a powerful model of human intestinal tumour predisposition. As such, it has provided a platform… 
2004
2004
The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration
2002
2002
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1
Highly Cited
2000
Highly Cited
2000
Regulation of Tiam1 Nucleotide Exchange Activity by Pleckstrin Domain Binding Ligands*
Rho family GTPases play roles in cytoskeletal organization and cellular transformation. Tiam1 is a member of the Dbl family of… 
Highly Cited
1999
Highly Cited
1999
Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells
Bufalin, a component of the Chinese medicine chan'su, induces apoptosis in various lines of human tumor cells, such as leukemia… 
Highly Cited
1996
Highly Cited
1996
Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning.
We generated a cDNA expression library from a human neuroepithelioma cell line for detection of novel oncogenes by focus… 
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