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TET2 gene

Known as: TET2, FLJ20032, TET ONCOGENE FAMILY, MEMBER 2 
This gene is involved in oxidation.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Cycle ControlMyelopoiesisNucleotide MetabolismOxidation-Reduction

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TET2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies1–3. In this… 
Highly Cited
2018
Highly Cited
2018
Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome.
Highly Cited
2017
Highly Cited
2017
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Faulty blood cells and heart disease Recent studies have shown that elderly people's blood cells often harbor mutations in genes… 
Highly Cited
2012
Highly Cited
2012
TET2 promotes histone O-GlcNAcylation during gene transcription
Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and… 
Highly Cited
2011
Highly Cited
2011
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes that alters the epigenetic status of DNA by… 
Highly Cited
2011
Highly Cited
2011
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies.
TET2 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies including MDS, CMML, MPN, and AML… 
Highly Cited
2010
Highly Cited
2010
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The… 
Highly Cited
2010
Highly Cited
2010
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Highly Cited
2009
Highly Cited
2009
Acquired mutations in TET2 are common in myelodysplastic syndromes
Myelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic hematopoietic disorders. Several recurrent… 
Highly Cited
2009
Highly Cited
2009
Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms.
Chromosomal abnormalities are frequent in myeloid malignancies, but in most cases of myelodysplasia (MDS) and myeloproliferative… 
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