TDP-43 Proteinopathies

Known as: TDP-43 Proteinopathies [Disease/Finding], TDP-43 Proteinopathy, TDP 43 Proteinopathies 
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in amyotrophic lateral sclerosis (ALS) and a… (More)
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Highly Cited
2011
Highly Cited
2011
We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to identify binding sites in 6,304 genes as… (More)
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Highly Cited
2010
Highly Cited
2010
Neuropathology involving TAR DNA binding protein-43 (TDP-43) has been identified in a wide spectrum of neurodegenerative diseases… (More)
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Highly Cited
2009
Highly Cited
2009
The disease protein in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral… (More)
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Highly Cited
2009
Highly Cited
2009
Inclusions of TAR DNA-binding protein-43 (TDP-43), a nuclear protein that regulates transcription and RNA splicing, are the… (More)
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Highly Cited
2008
Highly Cited
2008
Accumulation of hyperphosphorylated, ubiquitinated and N-terminally truncated TAR DNA-binding protein (TDP-43) is the… (More)
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Highly Cited
2008
Highly Cited
2008
Protein misfolding is intimately associated with devastating human neurodegenerative diseases, including Alzheimer's, Huntington… (More)
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Highly Cited
2007
Highly Cited
2007
Here, we investigated if TAR-DNA-binding protein-43 (TDP-43), the disease protein in frontotemporal lobar degeneration and… (More)
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Highly Cited
2007
Highly Cited
2007
TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and familial frontotemporal lobar degeneration… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE This study aimed to determine the frequency of frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U… (More)
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