TBX5 gene

Known as: T-BOX 5, T-Box 5 Gene, TBX5 
This gene is involved in transcriptional regulation and mesoderm differentiation.
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Congenital heart defects (CHDs) are the most common developmental anomaly and are the leading non-infectious cause of mortality… (More)
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Highly Cited
2002
Highly Cited
2002
The T-box genes Tbx4 and Tbx5 have been shown to have key functions in the specification of the identity of the vertebrate… (More)
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Highly Cited
2001
Highly Cited
2001
The cardiac homeobox protein Nkx2-5 is essential in cardiac development, and mutations in Csx (which encodes Nkx2-5) cause… (More)
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Highly Cited
2000
Highly Cited
2000
The T-box gene tbx5 is expressed in the developing heart, forelimb, eye, and liver in vertebrate embryos during critical stages… (More)
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Highly Cited
1999
Highly Cited
1999
Mutations in the Tbx5 transcription factor cause heart septal defects found in human Holt-Oram Syndrome. The complete extent to… (More)
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Highly Cited
1999
Highly Cited
1999
During embryonic development, initially similar fields can develop into distinct structures, such as the vertebrate fore- and… (More)
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Highly Cited
1999
Highly Cited
1999
To better understand the role of TBX5, a T-box containing transcription factor in forelimb and heart development, we have studied… (More)
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Highly Cited
1999
Highly Cited
1999
To further define the role of a T-box transcription factor, Tbx5, in cardiac development, we have examined its expression in the… (More)
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Highly Cited
1997
Highly Cited
1997
Holt-Oram syndrome is a developmental disorder affecting the heart and upper limb, the gene for which was mapped to chromosome 12… (More)
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Highly Cited
1997
Highly Cited
1997
Holt-Oram syndrome is characterized by upper limb malformations and cardiac septation defects. Here, we demonstrate that… (More)
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