TBK1 protein, human

Known as: TANK Binding Kinase TBK1, NF-kB-activating kinase protein, human, TANK-binding kinase 1 protein, human 
Encoded by human TBK1 Gene, 729-aa 84-kDa TANK-Binding Kinase 1 (similar to IKB kinases) mediates NFKB activation in response to certain growth… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative syndrome hallmarked by adult-onset loss of… (More)
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Highly Cited
2012
Highly Cited
2012
Cytosolic double-stranded DNA (dsDNA) stimulates the production of type I interferon (IFN) through the endoplasmic reticulum (ER… (More)
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Highly Cited
2009
Highly Cited
2009
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard… (More)
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Highly Cited
2008
Highly Cited
2008
Viral infection triggers activation of transcription factors such as NF-kappaB and IRF3, which collaborate to induce type I… (More)
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Highly Cited
2008
Highly Cited
2008
TANK-binding kinase 1 (TBK1) was identified as a binding partner for Optineurin (OPTN) in two-hybrid screens, an interaction… (More)
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Highly Cited
2006
Highly Cited
2006
The monomeric RalGTPases, RalA and RalB are recognized as components of a regulatory framework supporting tumorigenic… (More)
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Highly Cited
2006
Highly Cited
2006
Toll-like receptors (TLRs) are activated by pathogen-associated molecular patterns to induce innate immune responses and… (More)
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Highly Cited
2004
Highly Cited
2004
Virus infection, double-stranded RNA, and lipopolysaccharide each induce the expression of genes encoding IFN-alpha and -beta and… (More)
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Highly Cited
1999
Highly Cited
1999
The activation of NF-kappaB by receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor… (More)
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Highly Cited
1992
Highly Cited
1992
Experiments designed to examine the energy requirements of neurophysiological function were performed on isolated rabbit retina… (More)
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