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Background Bitter taste receptors (T2R) have recently been demonstrated to contribute to sinonasal innate immunity. One T2R… Expand Salicin from willow bark has been used throughout centuries in China and Europe for the treatment of pain, headache, and… Expand Human driven selection during domestication and subsequent breed formation has likely left detectable signatures within the… Expand In mammals, bitter taste is mediated by TAS2R genes, which belong to the large family of seven transmembrane G protein-coupled… Expand Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs) expressed in gustatory cells. Each… Expand Widespread multifactor interactions present a significant challenge in determining risk factors of complex diseases. Several… Expand BACKGROUND
A novel family of G protein-coupled receptors, TAS2Rs, has recently been characterized and linked to sensitivity to… Expand Alcoholism is a complex disorder with both genetic and environmental risk factors. Studies in humans have begun to elucidate the… Expand BACKGROUND
During periods of human expansion into new environments, recognition of bitter natural toxins through taste may have… Expand Bitter taste generally causes aversion, which protects humans from ingesting toxic substances. But bitter flavors also contribute… Expand