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TAK 603
Known as:
TAK-603
Â
Â
National Institutes of Health
Topic mentions per year
Topic mentions per year
1996-2006
0
1
2
3
1996
2006
Related topics
Related topics
2 relations
Broader (2)
Quinolines
Triazoles
Related mentions per year
Related mentions per year
1946-2018
1940
1960
1980
2000
2020
TAK 603
Triazoles
Quinolines
Papers overview
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2006
2006
TAK-603, an anti-inflammatory compound, reduces crescentic glomerulonephritis and preserves renal function in WKY rats.
Junya Yamahana
,
Takashi Wada
,
Kengo Furuichi
,
Norihiko Sakai
,
Hitoshi Yokoyama
,
Shuichi Kaneko
Nephrology, dialysis, transplantation : official…
2006
BACKGROUND The therapeutic efficacy of the regulation of T helper (Th)-1-predominant immune responses remains to be investigated…Â
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2001
2001
Prevention of lethal acute graft-versus-host disease in mice by oral administration of T helper 1 inhibitor, TAK-603.
Y. Lu
,
Sumio Sakamaki
,
+12 authors
Yoichi Niitsu
Blood
2001
Acute graft-versus-host diseases (GVHD) is a major cause of morbidity and mortality in patients undergoing allogeneic bone marrow…Â
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1999
1999
Possible factor for nonlinear pharmacokinetics of TAK-603, a new antirheumatic agent, in rats.
Yoshihiko Tagawa
,
Keisuke Miwa
,
+4 authors
Yusuke Tanigawara
Biopharmaceutics & drug disposition
1999
A new antirheumatic, TAK-603, shows nonlinear pharmacokinetics in both animals and humans. To elucidate the mechanism of these…Â
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1999
1999
Studies on disease-modifying antirheumatic drugs. III. Bone resorption inhibitory effects of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl) quinoline-3-carboxylate (TAK-603…
Atsuo Baba
,
T. Oda
,
+4 authors
Takashi Sohda
Chemical & pharmaceutical bulletin
1999
In the course of our studies aimed at obtaining new drugs for treatment of bone and joint diseases, chemical modification of the…Â
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1999
1999
Effect of its demethylated metabolite on the pharmacokinetics of unchanged TAK-603, a new antirheumatic agent, in rats.
Yoshihiko Tagawa
,
Keisuke Miwa
,
Ryoichi Tsukuda
,
Y. Yoshimura
,
S Tanayama
,
Yusuke Tanigawara
Drug metabolism and disposition: the biological…
1999
A factor in the dose-dependent pharmacokinetics of ethyl 4-(3, 4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2, 4-triazol-1-yl-methyl…Â
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1998
1998
Disposition of the new antirheumatic agent ethyl 4-(3,4-dimethoxyphenyl)- 6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) in rats and dogs.
Y. Tagawa
,
Yuka Kiyota
,
Y. Yoshimura
,
Masafumi Motohashi
,
S Tanayama
Arzneimittel-Forschung
1998
The disposition of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4- triazol-1-ylmethyl) quinoline-3-carboxylate (CAS 158146…Â
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1998
1998
Studies on disease-modifying antirheumatic drugs. II. Synthesis and activity of the metabolites of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quino line-3-carboxylate…
Atsuo Baba
,
H. Makino
,
Y. Ohta
,
Takashi Sohda
Chemical & pharmaceutical bulletin
1998
The metabolites of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmeth yl)quinoline -3-carboxylate (1, TAK-603…Â
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1998
1998
Double column-switching high-performance liquid chromatographic method for the determination of TAK-603 and its metabolites in human serum.
Tatsunobu Hagimoto
,
Jun-ichi Okada
,
Masafumi Motohashi
,
Y. Yoshimura
Journal of chromatography. B, Biomedical sciences…
1998
A double column-switching high-performance liquid chromatographic (HPLC) method for the determination of concentrations for TAK…Â
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1997
1997
TAK-603 selectively suppresses Th1-type cytokine production and inhibits the progression of adjuvant arthritis.
Y. Ohta
,
Masako Yamane
,
Takashi Sohda
,
H. Makino
Immunology
1997
We have shown that TAK-603, a new anti-rheumatic drug, is more effective in animal models in which cellular immunity plays a…Â
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1996
1996
Immunomodulating and articular protecting activities of a new anti-rheumatic drug, TAK-603.
Y. Ohta
,
Shinsaku Fukuda
,
+4 authors
H. Makino
Immunopharmacology
1996
We investigated the pharmacological activities of a newly synthesized anti-rheumatic drug, TAK-603. (1) In vivo: In adjuvant…Â
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