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TAK 285

Known as: EGFR/HER2 Kinase Inhibitor TAK-285, TAK-285, TAK285 
An orally bioavailable, small molecule and dual kinase inhibitor of human epidermal growth factor receptors 1 (EGFR/ErbB1) and 2 (HER2/ErbB2), with… Expand
National Institutes of Health

Papers overview

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2015
2015
The gatekeeper T798M mutation in HER2 kinase domain has been observed to considerably shift drug sensitivity to HER2 in breast… Expand
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2014
2014
The human epidermal growth factor receptor (HER) family plays a major role in cancer cell proliferation. Overexpression of these… Expand
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2013
2013
Breast cancer therapy has improved following the development of drugs with specific molecular targets, exemplified by inhibitors… Expand
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2013
2013
The epidermal growth factor receptor (EGFR) family plays a critical role in vital cellular processes and in various cancers… Expand
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2013
2013
SummaryIntroduction This phase 1 study assessed safety, maximum tolerated dose (MTD), pharmacokinetics, cerebrospinal fluid (CSF… Expand
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2012
2012
Background:This phase I first-in-human study was conducted in Japanese patients to investigate the safety, pharmacokinetics (PKs… Expand
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2012
2012
TAK-285, an investigational, orally active HER2/EGRF inhibitor is in clinical development for potential use in HER2 over… Expand
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2012
2012
During the course of our studies on a novel HER2/EGFR dual inhibitor (TAK-285), we found an alternative potent pyrrolo[3,2-d… Expand
Highly Cited
2011
Highly Cited
2011
Aberrant signaling of ErbB family members human epidermal growth factor 2 (HER2) and epidermal growth factor receptor (EGFR) is… Expand
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Highly Cited
2011
Highly Cited
2011
Dual inhibitors of human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR) have been… Expand