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TAE226

 
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
BACKGROUND AND PURPOSE Focal adhesion kinase (FAK), a main player in integrin signaling and survival, is frequently overexpressed… Expand
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2009
2009
SummaryNeoangiogenesis plays an important role in tumor growth and metastasis. Evaluation of new anti-angiogenic targets may… Expand
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Highly Cited
2008
Highly Cited
2008
Focal adhesion kinase (FAK) is a nonreceptor kinase that is overexpressed in many types of tumors. We developed a novel cancer… Expand
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Highly Cited
2008
Highly Cited
2008
Focal adhesion kinase, FAK is a 125 kDa nonreceptor tyrosine kinase that localizes to focal adhesions. FAK is overexpressed in… Expand
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Highly Cited
2008
Highly Cited
2008
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK… Expand
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2008
2008
Purpose. Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is… Expand
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2008
2008
Purpose: Focal adhesion kinase (FAK) regulates integrin and growth factor–mediated signaling pathways to enhance cell migration… Expand
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Highly Cited
2007
Highly Cited
2007
Focal adhesion kinase (FAK) overexpression is frequently found in ovarian and other cancers and is predictive of poor clinical… Expand
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Highly Cited
2007
Highly Cited
2007
Glioblastomas are highly lethal cancers that resist current therapies. Novel therapies under development target molecular… Expand
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Highly Cited
2007
Highly Cited
2007
Multiple genetic aberrations in human gliomas contribute to their highly infiltrative and rapid growth characteristics. Focal… Expand
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