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TAE226

 
National Institutes of Health

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1 relation

Broader (1)

Morpholines

Papers overview

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Highly Cited
2009
Highly Cited
2009
3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226.
BACKGROUND AND PURPOSE Focal adhesion kinase (FAK), a main player in integrin signaling and survival, is frequently overexpressed… Expand
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2009
2009
TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis
SummaryNeoangiogenesis plays an important role in tumor growth and metastasis. Evaluation of new anti-angiogenic targets may… Expand
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Highly Cited
2008
Highly Cited
2008
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.
Focal adhesion kinase (FAK) is a nonreceptor kinase that is overexpressed in many types of tumors. We developed a novel cancer… Expand
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Highly Cited
2008
Highly Cited
2008
TAE226‐Induced apoptosis in breast cancer cells with overexpressed Src or EGFR
Focal adhesion kinase, FAK is a 125 kDa nonreceptor tyrosine kinase that localizes to focal adhesions. FAK is overexpressed in… Expand
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Highly Cited
2008
Highly Cited
2008
Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK… Expand
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2008
2008
TAE226 Inhibits Human Neuroblastoma Cell Survival
Purpose. Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is… Expand
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2008
2008
Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo
Purpose: Focal adhesion kinase (FAK) regulates integrin and growth factor–mediated signaling pathways to enhance cell migration… Expand
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Highly Cited
2007
Highly Cited
2007
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma.
Focal adhesion kinase (FAK) overexpression is frequently found in ovarian and other cancers and is predictive of poor clinical… Expand
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Highly Cited
2007
Highly Cited
2007
A novel low‐molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth
Glioblastomas are highly lethal cancers that resist current therapies. Novel therapies under development target molecular… Expand
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Highly Cited
2007
Highly Cited
2007
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
Multiple genetic aberrations in human gliomas contribute to their highly infiltrative and rapid growth characteristics. Focal… Expand
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