TAE226

 
National Institutes of Health

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Papers overview

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2012
2012
Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma.
OBJECTIVES Focal adhesion kinase (FAK) overexpression is frequently found in invasive and metastatic cancers, but its role in… (More)
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2009
2009
3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226.
BACKGROUND AND PURPOSE Focal adhesion kinase (FAK), a main player in integrin signaling and survival, is frequently overexpressed… (More)
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2009
2009
TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis
Neoangiogenesis plays an important role in tumor growth and metastasis. Evaluation of new anti-angiogenic targets may broaden the… (More)
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2008
2008
TAE226 inhibits human neuroblastoma cell survival.
PURPOSE Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is… (More)
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2008
2008
TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR.
Focal adhesion kinase, FAK is a 125 kDa nonreceptor tyrosine kinase that localizes to focal adhesions. FAK is overexpressed in… (More)
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Highly Cited
2008
Highly Cited
2008
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.
Focal adhesion kinase (FAK) is a nonreceptor kinase that is overexpressed in many types of tumors. We developed a novel cancer… (More)
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2008
2008
Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK… (More)
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Highly Cited
2007
Highly Cited
2007
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.
Glioblastomas are highly lethal cancers that resist current therapies. Novel therapies under development target molecular… (More)
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Highly Cited
2007
Highly Cited
2007
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma.
Focal adhesion kinase (FAK) overexpression is frequently found in ovarian and other cancers and is predictive of poor clinical… (More)
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Highly Cited
2007
Highly Cited
2007
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.
Multiple genetic aberrations in human gliomas contribute to their highly infiltrative and rapid growth characteristics. Focal… (More)
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