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TAC 278

Known as: 5-Pyrimidinecarboxylic acid, 4-butoxy-5-fluorohexahydro-2,6-dioxo-, ethyl ester, TAC-278 
National Institutes of Health

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2 relations

Broader (1)

Fluorouracil
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Studies on the designing of chemotherapy for gastric cancer in man, based on the tumor tissue concentration of anticancer agents
Summary5-fluorouracil analogs investigated in this study include a combination of uracil and Ftorafur (UFT), Ethyl (±)-t-butoxy-5… 
1983
1983
[Cerebrospinal fluid distributions of systemically administered fluorinated pyrimidines].
Transfer of systemically administered fluorinated pyrimidines (Tegafur, TAC-278, HCFU and FD-1) to cerebrospinal fluid was… 
1982
1982
[Pharmacological and pharmacodynamic aspects of cancer chemotherapy, with special reference to 5-fluorouracil and its derivatives].
5-FU analogs being investigated in Japan are; 5-FU, FT, FD-1, HCFU, UFT, TAC-278, 5'-DFUR, FF-705, and TK-117. They exert… 
1982
1982
[Phase I clinical study of a new fluorinated pyrimidine antineoplastic agent, TAC-278].
A new fluorinated pyrimidine, TAC-278, was studied for its safety, anti-tumor activity and pharmacokinetics in patients with… 
1982
1982
[TAC-278. A new 5-FU derivative, by the oral route for its efficacy and safety in 36 patients with advanced cancers].
Tumor regression was observed in only one patient. Twelve (33%) of the 36 patients reported adverse effects: gastrointestinal… 
1982
1982
[Phase II study of a new fluorinated pyrimidine, ethyl (+/-)-t-6-butoxy-5-fluoro-2, 4-dioxohexahydropyrimidine-r-5-carboxylate (TAC-278)].
A Phase II study of a new fluorinated pyrimidine (TAC-278) was performed in 14 institutions from May 1980 to April 1981. 400-1200… 
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