FAQ

TAB3 gene

Known as: TAK1-BINDING PROTEIN 3, NF-KAPPA-B-ACTIVATING PROTEIN 1, MAP3K7IP3 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2017
024620032017

Papers overview

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Highly Cited
2012
Highly Cited
2012
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α
Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune diseases. Although several microRNAs… (More)
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2011
2011
Inhibition of autophagy by TAB2 and TAB3.
Autophagic responses are coupled to the activation of the inhibitor of NF-κB kinase (IKK). Here, we report that the essential… (More)
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2009
2009
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3.
TAB2 and TAB3 activate the Jun N-terminal kinase and nuclear factor-kappaB pathways through the specific recognition of Lys 63… (More)
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Highly Cited
2008
Highly Cited
2008
TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation
Toll-like receptor (TLR) signaling is pivotal to innate and adaptive immune responses and must be tightly controlled. The… (More)
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2008
2008
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
The protein kinase TAK1 (transforming growth factor-beta-activated kinase 1), which has been implicated in the activation of MAPK… (More)
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2007
2007
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
Transforming growth factor-β1 (TGF-β1) regulates inflammation and can inhibit activation of the transcription factor NF-κB in… (More)
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Highly Cited
2004
Highly Cited
2004
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.
The activation of NF-kappaB and IKK requires an upstream kinase complex consisting of TAK1 and adaptor proteins such as TAB1… (More)
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Highly Cited
2004
Highly Cited
2004
TAB3, a new binding partner of the protein kinase TAK1.
We have identified a new binding partner of the TGFbeta (transforming growth factor-beta)-activated protein kinase (TAK1), termed… (More)
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2004
2004
Identification of a human NF-kappaB-activating protein, TAB3.
The NF-kappaB pathway plays a critical role in regulating cellular processes such as immune responses, stress responses… (More)
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Highly Cited
2003
Highly Cited
2003
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.
The cytokines IL-1 and TNF induce expression of a series of genes that regulate inflammation through activation of NF-kappaB… (More)
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