FAQ

T-tubule organization

Known as: T-tubule organisation, T-tubule organization and biogenesis 
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2017
0120062017

Related topics

Related topics

2 relations

Broader (2)

muscle cell developmentplasma membrane organization

Related mentions per year

Related mentions per year

1975-2018
197019801990200020102020
T-tubule organization
plasma membrane organization
muscle cell development

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation
Atrial fibrillation is the most common arrhythmia, yet treatment strategies are sub-optimal due to incomplete understanding of… (More)
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2016
2016
Effects of induced Na+/Ca2+ exchanger overexpression on the spatial distribution of L-type Ca2+ channels and junctophilin-2 in pressure-overloaded hearts.
The Na+/Ca2+ exchanger 1 (NCX1) is an essential Ca2+ efflux system in cardiomyocytes. Although NCX1 is distributed throughout the… (More)
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Review
2015
Review
2015
In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused hearts
Transverse tubules (T-tubules) are orderly invaginations of the sarcolemma in mammalian cardiomyocytes. The integrity of T-tubule… (More)
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2014
2014
Ultrastructural and cellular basis for the development of abnormal myocardial mechanics during the transition from hypertension to heart failure.
Although the development of abnormal myocardial mechanics represents a key step during the transition from hypertension to overt… (More)
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2013
2013
Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity.
Recent work has demonstrated that cardiomyocyte Ca(2+)release is desynchronized in several pathological conditions. Loss of Ca(2… (More)
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2012
2012
β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction.
β-Adrenergic receptor (AR) blockers provide substantial clinical benefits, including improving overall survival and left… (More)
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2012
2012
Spatial variability in T-tubule and electrical remodeling of left ventricular epicardium in mouse hearts with transgenic Gαq overexpression-induced pathological hypertrophy.
Pathological left ventricular hypertrophy (LVH) is consistently associated with prolongation of the ventricular action potentials… (More)
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2011
2011
PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes
BACKGROUND Phosphoinositide 3-kinases (PI3Ks) regulate numerous physiological processes including some aspects of cardiac… (More)
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Highly Cited
2009
Highly Cited
2009
Loss of Myotubularin Function Results in T-Tubule Disorganization in Zebrafish and Human Myotubular Myopathy
Myotubularin is a lipid phosphatase implicated in endosomal trafficking in vitro, but with an unknown function in vivo. Mutations… (More)
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Highly Cited
2006
Highly Cited
2006
T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarction.
In cardiac myocytes, initiation of excitation-contraction coupling is highly localized near the T-tubule network. Myocytes with a… (More)
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