T follicular helper cell differentiation
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T follicular helper (Tfh) cells are a specialized population of CD4+ T cells that provide help to B cells for the formation and… Expand Key Points Bach2 deletion in CD4+ T cells results in preferential Tfh cell differentiation. The CXCR5 induction in the absence of… Expand T follicular helper cells (Tfh) are important regulators of humoral responses. Human Tfh polarization pathways have been thus far… Expand Adenosine A2a receptor (A2aR) signaling acts as a barrier to autoimmunity by promoting anergy, inducing regulatory T cells, and… Expand Naturally acquired immunity to malaria develops only after years of repeated exposure to Plasmodium parasites. Despite the key… Expand T follicular helper (Tfh) cell is a unique T cell subset specialized in promoting humoral immunity. B-cell lymphoma 6 protein… Expand IL-12 is important for the differentiation of T follicular helper (Tfh) cells, as well as Th1 cells in humans. Still, how IL-12… Expand T follicular helper (Tfh) cells are essential for the formation of germinal centers (GCs) and the development of long-lived… Expand Summary T follicular helper (Tfh) cells are essential for efficient B cell responses, yet the factors that regulate… Expand Significance Most vaccines protect from infections by eliciting a long-lived antibody response. B-cell CLL/lymphoma 6 (Bcl6) is a… Expand