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T cell receptor V(D)J recombination

Known as: T cell receptor V-D-J recombination, T cell receptor V(D)J joining, T cell receptor V-J joining 
The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Nuclear processes such as transcription, DNA replication and recombination are dynamically regulated by chromatin structure… Expand
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Review
2006
Review
2006
Mammals contend with a universe of evolving pathogens by generating an enormous diversity of antigen receptors during lymphocyte… Expand
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Highly Cited
2005
Highly Cited
2005
The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have… Expand
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Review
2002
Review
2002
  • M. Gellert
  • Annual review of biochemistry
  • 2002
  • Corpus ID: 46413491
V(D)J recombination is the specialized DNA rearrangement used by cells of the immune system to assemble immunoglobulin and T-cell… Expand
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Highly Cited
2002
Highly Cited
2002
Mutations in the Artemis protein in humans result in hypersensitivity to DNA double-strand break-inducing agents and absence of B… Expand
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Highly Cited
1996
Highly Cited
1996
Double-stranded DNA breaks (DSBs) trigger p53-mediated cell cycle arrest or apoptosis pathways that limit the oncogenic… Expand
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Highly Cited
1995
Highly Cited
1995
Formation of double-strand breaks at recombination signal sequences is an early step in V(D)J recombination. Here we show that… Expand
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Highly Cited
1993
Highly Cited
1993
Immunoglobulin and T-cell receptor genes are assembled during lymphocyte development by a novel, highly regulated series of gene… Expand
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Highly Cited
1990
Highly Cited
1990
The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic… Expand
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Highly Cited
1989
Highly Cited
1989
The RAG-1 (recombination activating gene-1) genomic locus, which activates V(D)J recombination when introduced into NIH 3T3… Expand
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