T cell receptor V(D)J recombination

Known as: T cell receptor V-D-J recombination, T cell receptor V(D)J joining, T cell receptor V-J joining 
The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus… (More)
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Nuclear processes such as transcription, DNA replication and recombination are dynamically regulated by chromatin structure… (More)
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Review
2006
Review
2006
Mammals contend with a universe of evolving pathogens by generating an enormous diversity of antigen receptors during lymphocyte… (More)
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Review
2006
Review
2006
When a single double-strand break arises in the genome, nonhomologous DNA end joining (NHEJ) is a major pathway for its repair… (More)
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Highly Cited
2005
Highly Cited
2005
The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have… (More)
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Review
2002
Review
2002
V(D)J recombination is the specialized DNA rearrangement used by cells of the immune system to assemble immunoglobulin and T-cell… (More)
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Highly Cited
2002
Highly Cited
2002
Mutations in the Artemis protein in humans result in hypersensitivity to DNA double-strand break-inducing agents and absence of B… (More)
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Highly Cited
1995
Highly Cited
1995
Cells performing V(D)J recombination make specific cuts in DNA at recombination signal sequences. Here, we show that nuclear… (More)
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Highly Cited
1993
Highly Cited
1993
Immunoglobulin and T-cell receptor genes are assembled during lymphocyte development by a novel, highly regulated series of gene… (More)
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Highly Cited
1990
Highly Cited
1990
The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic… (More)
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Highly Cited
1989
Highly Cited
1989
The RAG-1 (recombination activating gene-1) genomic locus, which activates V(D)J recombination when introduced into NIH 3T3… (More)
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