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T cell receptor V(D)J recombination

Known as: T cell receptor V-D-J recombination, T cell receptor V(D)J joining, T cell receptor V-J joining 
The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus… 
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Epigenetic regulation of V(D)J recombination.
Chromosome breaks are dangerous business, carrying the risk of loss of genetic information or, even worse, misrepair of the break… 
2010
2010
ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo
V(D)J recombination is essential for the maturation of lymphocytes. Because of the involvement of cutting and joining DNA double… 
2006
2006
Identification and Characterization of a Gain-of-Function RAG-1 Mutant
ABSTRACT RAG-1 and RAG-2 initiate V(D)J recombination by cleaving DNA at recombination signal sequences through sequential… 
2004
2004
Paradigm switching in the germinal center
Antigen receptor genes are assembled by a sequence of lineage-specific recombinatorial events, in which DNA breaks must be… 
2002
2002
Characterization of Chromatin Structure and Enhancer Elements for Murine Recombination Activating Gene-21
Recombination-activating genes (RAGs) play a critical role in V(D)J recombination machinery and their expression is specifically… 
2002
2002
Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC
The large zinc finger protein KRC binds to the signal sequences of V(D)J recombination and the κB motif. Disruption of KRC… 
Review
2002
Review
2002
V(D)J recombination and DNA repair: lessons from human immune deficiencies and other animal models
Purpose of reviewV(D)J recombination not only represents the main mechanism for the diversification of the immune system, it also… 
1997
1997
Quantification of hprt gene deletions mediated by illegitimate V(D)J recombination in peripheral blood cells of humans
V(D)J recombinase is normally involved in the highly regulated rearrangement of immunoglobulin and T‐cell‐receptor gene segments… 
1996
1996
The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family…
Rc is a DNA binding protein with dual specificities for the V(D)J recombination signal sequences and for the B motif of the… 
1994
1994
Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate.
The immunoglobulin heavy chain intronic transcriptional enhancer (E mu) is part of a complex cis-regulatory DNA region which has… 
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